The CCFR Resource

The CCFR comprises a rich resource of data and biospecimens that has been growing since 1998. See below for an overview1 of the available resources we provide to world leading research.

Recruitment Summary

15,050 Families
42,501 Participants
32,790 Population-based Participants
9,711 Clinic-based Participants

Colorectal Cancer Status

Probands with2 colorectal cancer: 10,030
Probands without3 colorectal cancer: 4,766
Relatives with colorectal cancer: 2,342
Relatives without colorectal cancer: 25,363
Colorectal cancers diagnosed since recruitment: 1,285

Collected Materials

Blood/saliva samples donated by participants: 32,164

Participants with:

  • a prevalent CRC tumor specimen (diagnosed prior to recruitment): 8,785
  • an incident CRC tumor specimen (diagnosed since recruitment): 397
  • a prevalent non-CRC tumor specimen (diagnosed prior to recruitment): 651
  • an incident non-CRC tumor specimen (diagnosed since recruitment): 254
­ RECRUITMENTMaleFemaleTotal
Population-based families

 

 

13,191

Probands with colorectal cancer4,3214,4188,739
 Relatives with colorectal cancer521

564

1,085

 Relatives without colorectal cancer7,2099,77316,982
Spouse Controls369565934

Proband Controls2,071

2,2024,273

 Relatives310467777
Total population-based participants 14,80117,98932,790
Clinic-based families

 

 

1,859
Probands with colorectal cancer7156711,386
Probands without colorectal cancer121277398
 Relatives with colorectal cancer5896271,216
 Relatives without colorectal cancer2,9343,7776,711
Total clinic-based participants 4,3595,3529,711

 

 

 

 

Total Participants19,16023,34142,501
Total Families15,040

Participant Age at Enrolment

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Participation Since Baseline*

*Excludes population-based control families as they were not followed up.

Collected Materials

Population-based families (N=13,191)Probands with
colorectal cancer
Relatives with
colorectal cancer		Relatives without
colorectal cancer		Controls
Baseline epidemiologic survey data8,7391,08516,9825,984
1st (~5-year) follow-up epidemiologic/risk-factor survey data5,63777613,6832,044
2nd (~10-year) follow-up epidemiologic/risk-factor survey data4,07458311,0121,250
3rd (~15-year) follow-up epidemiologic/risk-factor survey data2,8913998,306496
4th (~20-year) follow-up epidemiologic/risk-factor survey data1,7062045,083

346

5th (~25-year) follow-up epidemiologic/risk-factor survey data5303089119
Baseline Food Frequency Questionnaire (FFQ) data4,5005177,3733,347
Cause of death data3,0342841,344478
Total person life-years98,21514,274268,24653,768
– Blood samples (processed into plasma, buffy coat, ficoll -separated lymphocytes, and dried blood spots)7,53482810,3663,543
– Saliva/buccal samples30344832219
– EBV transformed lymphoblastoid cell lines1,48058791,237
– Germline MMR (MLH1, MSH2, MSH6, PMS2 and/or EPCAM) data1,9212201,01345
– Germline MutYH data7,3241533,0312,541
– Genome-wide Association Studies (GWAS) data6,2842891,2942,764
Colorectal tissue material
– FFPE tumor tissue6,799494n/an/a
– FFPE normal tissue4,454251n/an/a
– Fresh frozen tumors412n/an/a
– Fresh frozen normal tissue473n/an/a
– CRC tumor 40x digitized H&E images (.svs format)4,755362n/an/a
– CRC tumor pathology report abstraction data8,143645n/an/a
– Clinical diagnosis and treatment abstraction data (Phase-I cases)3,980105n/an/a
– CRC tumor MMR (MSI and/or IHC) data6,811488n/an/a
– CRC tumor BRAFV600E data6,026319n/an/a
– CRC tumor KRAS codons 12 and 13 somatic mutation data6,012298n/an/a
– CRC tumor MLH1 promoter methylation data (tested if MLH1d)2,34080n/an/a
– CRC tumor CpG-island methylator phenotype (CIMP) data3,609154n/an/a
Colorectal (CR) FFPE polyps collected3514120n/a
– CR polyp pathology report abstraction data2,82923633814
Clinic-based families (N=1,860)Probands with
colorectal cancer		Probands without
colorectal cancer
Relatives with
colorectal cancer		Relatives without
colorectal cancer
Baseline epidemiologic survey data1,3863981,2166,711
1st Follow-up epidemiologic survey data1,0473669685,892
2nd Follow-up epidemiologic survey data8603287635,068
3rd Follow-up epidemiologic survey data6092505383,783
4th Follow-up epidemiologic survey data288972631,744

5th Follow-up epidemiologic survey data3521379
Food Frequency Questionnaire (FFQ) data5102336943,793
Cause of death data27618126215
Total person life-years18,1945,77715,869101,543
– Blood samples (processed into plasma, buffy coat, ficoll -separated lymphocytes and dried blood spots)1,2713661,1025,860
– Saliva/buccal samples841361
– EBV transformed lymphoblastoid cell lines238562221
– Germline MMR (MLH1, MSH2, MSH6, PMS2 and/or EPCAM) data8022366732,693
– Germline MutYH data1,029882276
– Genome-wide Association Studies (GWAS) data38032336211
Colorectal tissue material
– FFPE tumors1,048n/a698n/a
– FFPE normal tissue463n/a370n/a
– Fresh frozen tumors109n/a0n/a
– Fresh frozen normal tissue116n/a1n/a
– CRC tumor 40x digitized H&E images (.svs format)849n/a383n/a
– CRC tumor pathology report abstraction data1,268n/a738n/a
– Clinical diagnosis and treatment abstraction data (Phase I)654n/a21n/a
– CRC tumor MMR (MSI and/or IHC) data1,076n/a568n/a
– CRC tumor BRAFv600E data896n/a431n/a
– CRC tumor KRAS codons 12 and 13 somatic mutation data919n/a501n/a
– CRC tumor MLH1 promoter methylation data (tested if MLH1d)406n/a232n/a
– CRC tumor CpG-island methylator phenotype (CIMP) data5817756n/a
Colorectal (CR) FFPE polyps collected12984124291
– CR polyp pathology report abstraction data37588265298
  1. Additional information can be provided on request by contacting Allyson or Maggie. ↩
  2. Diagnosed with colorectal cancer (CRC). CRC is defined as a malignant tumor with ICD-O3 site codes C18.0, C18.2 – C18.9, C19.9, C20.9, C21.8 and C26.0. ↩
  3. No known colorectal cancer (CRC) diagnosis ever. ↩