IHC

Module: molecular

Module Contents

  1. ihc


1CENTER_NOnumber (2,0)Required:true
Center identification number.
Allowable Values
11Sinai Health Systems (formerly Cancer Care Ontario)
12Cedars-Sinai & Cleveland Clinic (formerly USC Consortium)
13University of Melbourne
14University of Hawaii Cancer Center
15Mayo Clinic
16Fred Hutch, Seattle
17UCSF: University of California at San Franscisco (formerly CPIC, originally Northern California (NCCC))


2PERSON_IDstring (12)Required:true
Number that Uniquely Identifies an Individual.

3IHC_TEST_LABnumber (1,0)Required:true
Lab that conducted the results
Allowable Values
1CFR lab
2Clinical lab


4COLLECTION_CIDstring (40)Required:true
The label assigned by the center to all tissue associated with a single surgical event – resection or biopsy/endoscopy procedure.

5TEST_TISSUEnumber (1,0)Required:true
Type of tissue tested.
Allowable Values
1Cancer
2Contiguous (Adjacent) adenoma
3Colon Polyp
4Gastric polyp
5Sebaceous adenoma


6TUMOR_NOnumber (2,0)Required:true
Numbers labeling tumors of the individual. Numbers are not necessarily sequential.
Allowable Values
1 to 99 or -9, -15Range
-9NA/Out of scope: Tissue does not currently have a TUMOR_NO and is not cancer or contiguous adenoma
-15Information Unknown


7POLYP_NOnumber (2,0)Required:true
Sequential number over range of 1 to 99 to distinguish a polyp removed on a particular date. The tuple PERSON_ID, DATE_COLLECTED, and POLYP_NO uniquely identify a physical polyp globally within the CFR database.
Allowable Values
1 to 99 or -1, -9Range
-9NA/Out of scope. Tissue is not a polyp.
-1Polyp has IHC/MSI result but center is currently unable to locate polyp pathology information. Center review to obtain this information is currently underway.


8BLOCK_SPEC_CIDstring (40)Required:true
Unique local identifier used at a center to uniquely identify a block tissue specimen.

9METASTASISnumber (1,0)Required:true
Primary or metastatic tumor.
Allowable Values
1Primary
2Metastatasis
-9Test is not performed on cancerous tissue


10IHC_MLH1number (2,0)Required:true
IHC result for MSI test at locus MLH1
Allowable Values
0Negative – Expression absent and abnormal
1Positive – Expression present and normal
2Positive – Technically poor, probably positive
3Positive – Technically equivocal, not truly interpretable but if forced would be positive
4Negative – Technically poor, probably negative
5Negative – Technically equivocal, not truly interpretable but if forced would be negative
7Heterogeneous tumor – some areas lack expression and some have expression
8Reduced – expression reduced but not absent
-11Technical failure
-12Not tested
-13Quantity of tissue not sufficient


11IHC_MSH2number (2,0)Required:true
IHC result for MSI test at locus MSH2
Allowable Values
0Negative – Expression absent and abnormal
1Positive – Expression present and normal
2Positive – Technically poor, probably positive
3Positive – Technically equivocal, not truly interpretable but if forced would be positive
4Negative – Technically poor, probably negative
5Negative – Technically equivocal, not truly interpretable but if forced would be negative
7Heterogeneous tumor – some areas lack expression and some have expression
8Reduced – expression reduced but not absent
-11Technical failure
-12Not tested
-13Quantity of tissue not sufficient


12IHC_MSH6number (2,0)Required:true
IHC result for MSI test at locus MSH6
Allowable Values
0Negative – Expression absent and abnormal
1Positive – Expression present and normal
2Positive – Technically poor, probably positive
3Positive – Technically equivocal, not truly interpretable but if forced would be positive
4Negative – Technically poor, probably negative
5Negative – Technically equivocal, not truly interpretable but if forced would be negative
7Heterogeneous tumor – some areas lack expression and some have expression
8Reduced – expression reduced but not absent
-11Technical failure
-12Not tested
-13Quantity of tissue not sufficient


13IHC_PMS2number (2,0)Required:true
IHC result for MSI test at locus PMS2
Allowable Values
0Negative – Expression absent and abnormal
1Positive – Expression present and normal
2Positive – Technically poor, probably positive
3Positive – Technically equivocal, not truly interpretable but if forced would be positive
4Negative – Technically poor, probably negative
5Negative – Technically equivocal, not truly interpretable but if forced would be negative
7Heterogeneous tumor – some areas lack expression and some have expression
8Reduced – expression reduced but not absent
-11Technical failure
-12Not tested
-13Quantity of tissue not sufficient