Module: derived

Module Contents

d_MSI_IHC_STATUS_PERSON
- 1.CENTER_NO
- 2.PERSON_ID
- 3.IHC_STATUS_PERSON
- 4.MSI_STATUS_PERSON
- 5.MSIIHC_STATUS_PERSON

CENTER_NO

number (2,0)

Required:true

Center Identification Number.

Allowable Values
11	Sinai Health Systems (formerly Cancer Care Ontario)
12	University of Southern California Consortium (USCC)
13	University of Melbourne
14	University of Hawaii Cancer Center
15	Mayo Clinic
16	Fred Hutch, Seattle
17	University of California at San Francisco (UCSF) (formerly CPIC, originally Northern California (NCCC))

2	PERSON_ID	string (12)	Required:true
	Number that Uniquely Identifies an Individual.

IHC_STATUS_PERSON

number (1,0)

Required:true

IHC status of person tested. It considers IHC results for ALL colorectal cancer tumor types and excludes all non-colorectal malignancies, adenomas, metastases and in situ carcinomas. It does not restrict to qualifying tumors. Colorectal cancer is defined by ICDO3 site codes C180, C181, C182, C183, C184, C185, C186, C187, C188, C189, C199, C209, C218, C260 and a malignant tumor (BEHAV=3).

Allowable Values
-8	No data transmitted
-7	NA/Out of scope: Individual has IHC record, but no markers having values 0,1,2, or 4.
1	NORMAL MMR protein expression
2	ABSENCE of MMR protein expression

MSI_STATUS_PERSON

number (1,0)

Required:true

MSI status of person tested. It considers MSI results for ALL colorectal cancer tumor types and excludes all non-colorectal malignancies, adenomas, metastases and in situ carcinomas. It does not restrict to qualifying tumors. Colon cancer is defined by ICDO3 site codes C180, C181, C182, C183, C184, C185, C186, C187, C188, C189, C199, C209, C218, C260 and a malignant tumor (BEHAV=3).

Allowable Values
-8	No data transmitted
-7	NA/Out of scope: An MSI record, but no Stable, Low, or High tissue-level result recorded.
1	STABLE: No High or Low tissue-level results, but at least one Stable.
2	LOW: No High tissue-level results, but at least one Low.
3	HIGH: At least one High tissue-level result

MSIIHC_STATUS_PERSON

number (1,0)

Required:true

MMR status for person tested. An overall MMR status is derived per person by collating MSI and IHC results for ALL colorectal cancer tumor types and excluding all non-colorectal malignancies, adenomas, metastases and in situ carcinomas. It does not restrict to qualifying tumors.

Allowable Values
-8	No data transmitted from centers for MSI_STATUS_TISSUE -AND- IHC_STATUS_TISSUE
-7	NA/Out of Scope – MSI_STATUS_TISSUE and IHC_STATUS_TISSUE are -7; -OR-, one of them is -7 and the other is -8.
1	Proficient MMR 1 – MSI_STATUS_TISSUE is Stable (1) or Low (2) -OR- IHC_STATUS_TISSUE is Normal (1), but not both
2	Proficient MMR 2 – MSI_STATUS_TISSUE is Stable (1) or Low (2) -AND- IHC_STATUS_TISSUE is Normal (1) (both are true)
3	Defective MMR 1 – MSI_STATUS_TISSUE is High (3) -OR- IHC_STATUS_TISSUE is Absent (2), but not both
4	Defective MMR 2 – MSI_STATUS_TISSUE is High (3) -AND- IHC_STATUS_TISSUE is Absent (2) (both are true)