Module: colorectal-path

Module Contents

  1. colorectal-malig
    1.CENTER_NO
    2.PERSON_ID
    3.TUMOR_NO
    4.DT_EVAL
    5.BLOCK_SPEC_CID
    6.PROCEDURE_TYPE
    7.MAT_REV_SLIDE
    8.MAT_REV_PATH_RPT
    9.MAT_REV_HOSP_REC
    10.MAT_REV_CA_REGISTRY
    11.MAT_REV_UNK
    12.SPEC_EXAM
    13.PRIM_SITE_CAT
    14.PRIM_HIST_CAT
    15.PRIM_HIST_CAT_OTH_TXT
    16.TUMOR_SIZE
    17.GRADE
    18.MACROSC_TUM_PERF
    19.MARGIN
    20.LC_PERI
    21.LC_CROHN
    22.LC_INFIL
    23.LOC_EXCIS
    24.MARG_INV_DISTAL
    25.MARG_INV_PROXIMAL
    26.MARG_INV_RADIAL
    27.MARG_INV_UNKNOWN
    28.VEN_INV
    29.LYMPHATIC_INV
    30.PERINEURAL_INV
    31.NEOADJ_TRT
    32.NEOADJ_TRT_TYPE
    33.CLINICAL_T
    34.CLINICAL_N
    35.CLINICAL_M
    36.cTNM_STAGE
    37.T_STAGE
    38.LN
    39.LN_POS
    40.LN_EX
    41.DIST_SPREAD
    42.MET_SITE
    43.MET_SITE_BONE
    44.MET_SITE_BRAIN
    45.MET_SITE_LIVER
    46.MET_SITE_LUNG
    47.MET_SITE_NODES
    48.MET_SITE_OVARY
    49.MET_SITE_PERITONEAL
    50.MET_SITE_SMLBWL
    51.MET_SITE_OTHER
    52.MET_SITE_UNKNOWN
    53.MET_SITE_OTH_TXT
    54.MET_SITE_SRC
    55.pTNM_STAGE
    56.SYNCHRON
    57.ADJ_ADEN
    58.ADJ_ADEN_TYPE
    59.ADJ_SIZE
    60.ADJ_GRADE

1 CENTER_NO number (2,0) Required:true
Center identification number.
Allowable Values
11 Sinai Health Systems (formerly Cancer Care Ontario)
12 Cedars-Sinai & Cleveland Clinic (formerly USC Consortium)
13 University of Melbourne
14 University of Hawaii Cancer Center
15 Mayo Clinic
16 Fred Hutch, Seattle
17 UCSF: University of California at San Francisco (formerly CPIC, originally Northern California (NCCC))


2 PERSON_ID string (12) Required:true
Number that uniquely identifies an individual.

3 TUMOR_NO number (2,0) Required:true
Computer generated sequential number, starting with 1, assigned to each tumor for a given individual when entered into the local system. No adjustment is made when a tumor is deleted from the system. Tumor numbers are never reused. PERSON_NO, TUMOR_NO uniquely identifies each tumor in the CIS. Tumor number should correspond with information from the CANCER file from Volume I.
Allowable Values
1 to 99 Range


4 DT_EVAL string (8) Required:true
Date specimen evaluated by treating institution (not by CCFR site)
Allowable Values
YYYYMMDD  


5 BLOCK_SPEC_CID string (9) Required:false
Specimen ID number. Consists of concatenation of CENTER_NO (2 digit) + local specimen number (7 characters). References TISSUE file from Volume II Biospecimen Data Dictionary. F-121 : SPECIMEN_ID must begin with CENTER_NO (COLORECT_MALIG) F-200 : SPECIMEN_ID must begin with CENTER_NO (POLYPS)

6 PROCEDURE_TYPE number (1,0) Required:true
Surgical procedure from which the specimen was obtained.
Allowable Values
1 Biopsy
2 Resection
3 Polypectomy
9 Unknown


7 MAT_REV_SLIDE number (1,0) Required:true
Materials reviewed included slides.
Allowable Values
1 Yes
2 No
9 Unknown


8 MAT_REV_PATH_RPT number (1,0) Required:true
Materials reviewed included pathology report.
Allowable Values
1 Yes
2 No
9 Unknown


9 MAT_REV_HOSP_REC number (1,0) Required:true
Materials reviewed included hospital records.
Allowable Values
1 Yes
2 No
9 Unknown


10 MAT_REV_CA_REGISTRY number (1,0) Required:true
Materials reviewed included cancer registry data.
Allowable Values
1 Yes
2 No
9 Unknown


11 MAT_REV_UNK number (1,0) Required:true
Materials reviewed unknown.
Allowable Values
1 Yes
2 No
9 Unknown


12 SPEC_EXAM number (1,0) Required:true
Was specimen examined from primary site or metastatic site?.
Allowable Values
1 Primary site
2 Metastatic site
3 Both
9 Unknown


13 PRIM_SITE_CAT number (1,0) Required:true
Primary site of colorectal cancer; Should include hepatic and splenic flexures with transverse colon.
Allowable Values
1 Caecum (illeocaecal)
2 Ascending (hepatic flexure)
3 Transverse (splenic flexure)
4 Descending
5 Sigmoid
6 Rectum (rectosigmoid)
7 Appendix
9 Unknown/NOS/not reported


14 PRIM_HIST_CAT number (1,0) Required:true
Categorization of histologic type of colorectal primary site; In mucinous carcinomas at least 50% of the tumor comprises areas in which mucin secretion is abundant (more mucus than epithelium). Most poorly differentiated solid types include areas of adenocarcinoma and should not be called undifferentiated. In signet ring cell cancers, 50% of the tumor is composed of signet ring cells.
Allowable Values
1 Adenocarcinoma
2 Mucinous
3 Signet ring
4 Undifferentiated (including medullary)
5 Other
9 Unknown


15 PRIM_HIST_CAT_OTH_TXT string(250) Required:false
Specify primary histologic category text. (Answer if PRIM_HIST_CAT=5)

16 TUMOR_SIZE number (2,0) Required:true
Size (cm) of tumor.
Allowable Values
1 to 20 Range
0 No mass
99 Unknown


17 GRADE number (1,0) Required:true
Grade (worst); The worst area should be graded. Minor fragmentation of glands at the growing tumor margin should be ignored. Well-differentiated cancers have well-formed glands relatively uniform nuclear characteristics. There is a resemblance to adenomatous epithelium. Moderately differentiated cancers have irregular glands but a glandular architecture is still obvious. In poorly differentiated cancers glandular architecture is discerned with difficulty. These are well circumscribed with solid sheets and/or trabeculae and/or cribiforing and/or signet ring areas.
Allowable Values
1 Low grade/well differentiated/G1
2 Low grade/moderately differentiated/G2
3 High grade/poorly differentiated/G3
4 Undifferentiated/G4
9 Unknown


18 MACROSC_TUM_PERF number (1,0) Required:true
Macroscopic tumor perforation. (Do not confuse with microscopic penetration of serosal surface).
Allowable Values
1 Present
2 Absent
9 Unknown


19 MARGIN number (1,0) Required:false
Tumor margin; Cancers considered, as intermediate between expanding and infiltrating should be grouped with the expanding subset. An infiltrating growth pattern may be suspected by naked eye examination of the slide because the pink muscle and blue tumor are merged and difficult to distinguish. Microscopically, infiltrating cancers dissect between muscle bundles, often with a ''raining down'' pattern. There is often diffuse infiltration of fat, perineurial invasion and vascular invasion.
Allowable Values
1 Expanding/pushing
2 Infiltrating/irregular
9 Unknown


20 LC_PERI number (1,0) Required:false
Peritumoral lymphocytes; The presence of peritumoral lymphocytes indicates a distinct inflammatory cuff or cap at the deepest point of penetration of the tumor. The inflammatory cells include neutrophils, eosinophils, macrophages and plasma cells as well as lymphocytes.
Allowable Values
1 Yes
2 No
9 Unknown


21 LC_CROHN number (1,0) Required:false
Crohn''s-like Lymphocytes; The Crohn''s-like reaction refers to lymphocytes arranged in aggregates or nodules, mainly away from the cancer and in the perirectal or mesenteric fat. It is suggested that at least three lymphoid aggregates should be present in a section.
Allowable Values
1 Yes
2 No
9 Unknown


22 LC_INFIL number (1,0) Required:false
Tumor infiltrating lymphocytes. In marked infiltration, the malignant epithelium is peppered with lymphocytes. The ratio of nuclei (lymphocyte: epithelial) should be at least 1:10 (or at least 12 intraepithelial lymphocytes within a high power (40) field) in the most obviously affected areas (about 3% of cases). Mild infiltration means that the lymphocyte: epithelial ratio should be at least 1:25 (or at least 5 unequivocal intraepithelial lymphocytes within one high power (40) field) in the most obviously affected areas (about 17% of cases). None means a lower frequency or none detected after searching for one minute (about 80% if cases).
Allowable Values
1 Yes, marked
2 Yes, mild
3 No
9 Unknown


23 LOC_EXCIS number (1,0) Required:true
Local excision
Allowable Values
1 Complete (all margins negative for malignancy)
2 Incomplete (one or more margins positive for malignancy)
9 Unknown


24 MARG_INV_DISTAL number (1,0) Required:false
Did tumor reach surgical resection distal margin? (Answer if LOC_EXCIS=2)
Allowable Values
1 Yes
2 No
9 Unknown


25 MARG_INV_PROXIMAL number (1,0) Required:false
Did tumor reach surgical resection proximal margin? (Answer if LOC_EXCIS=2)
Allowable Values
1 Yes
2 No
9 Unknown


26 MARG_INV_RADIAL number (1,0) Required:false
Did tumor reach surgical resection radial margin? (Answer if LOC_EXCIS=2)
Allowable Values
1 Yes
2 No
9 Unknown


27 MARG_INV_UNKNOWN number (1,0) Required:false
Which surgical resection margin(s) involved are unknown? (Answer if LOC_EXCIS=2)
Allowable Values
1 Yes
2 No
9 Unknown


28 VEN_INV number (1,0) Required:false
Venous invasion (note: formerly called vascular invasion VAS_INV).
Allowable Values
1 Yes
2 No
9 Unknown


29 LYMPHATIC_INV number (1,0) Required:false
Lymphatic invasion.
Allowable Values
1 Yes
2 No
9 Unknown


30 PERINEURAL_INV number (1,0) Required:false
Perineural invasion.
Allowable Values
1 Yes
2 No
9 Unknown


31 NEOADJ_TRT number (1,0) Required:true
Neoadjuvant treatment.
Allowable Values
1 Yes
2 No
9 Unknown


32 NEOADJ_TRT_TYPE number (1,0) Required:false
Neoadjuvant treatment type. (Answer if NEOADJ_TRT=1)
Allowable Values
1 Chemotherapy
2 Radiation
3 Both
9 Unknown


33 CLINICAL_T number (1,0) Required:false
T stage of colorectal cancer (T of TNM). From treatment data. (Answer if NEOADJ_TRT=1)
Allowable Values
0 Tis
1 T1
2 T2
3 T3
4 T4
9 Unknown


34 CLINICAL_N number (1,0) Required:false
Positive nodes? From treatment data. (Answer if NEOADJ_TRT=1)
Allowable Values
1 Yes
2 No
9 Unknown


35 CLINICAL_M number (1,0) Required:false
Metastasis? From treatment data. (Answer if NEOADJ_TRT=1)
Allowable Values
1 Yes
2 No
9 Unknown (no definitive statement of distant spread).


36 cTNM_STAGE number (1,0) Required:false
TNM Stage - Only if reported. Do not derive. From treatment data. (Answer if NEOADJ_TRT=1)
Allowable Values
0 In-situ
1 I
2 II
3 III
4 IV
9 Unknown (if distant spread is unknown)


37 T_STAGE number (1,0) Required:true
T stage of colorectal cancer (T of TNM). Note: Formerly called T_STAGE_M.
Allowable Values
0 Tis
1 T1
2 T2
3 T3
4 T4
9 Unknown


38 LN number (1,0) Required:true
Positive nodes?
Allowable Values
1 Yes
2 No
9 Unknown


39 LN_POS number (2,0) Required:true
Number of positive nodes. Note: codes adopted from SEER & NAACCR standards.
Allowable Values
0 to 99 Range
0 All nodes examined negative
1-95 Number positive
96 96 or more positive nodes
97 Positive nodes, # of positive nodes not specified
98 No nodes examined
99 Unknown if nodes are positive or negative; not applicable


40 LN_EX number (2,0) Required:true
Total number of examined nodes. Note: codes adopted from SEER & NAACCR standards.
Allowable Values
0 to 90, 95, 96, 99 Range
0 No nodes examined
1 - 89 # of nodes examined
90 90 or more nodes examined
95 No nodes removed
96 Nodes examined: # unknown/not stated
99 Unknown if nodes examined; not applicable


41 DIST_SPREAD number (1,0) Required:true
Distant spread - colorectal cancer (M in TNM)
Allowable Values
1 Yes
2 No
9 Unknown


42 MET_SITE number (1,0) Required:false
Metastatic site. Note: Only used for records received before January 20 2020.
Allowable Values
1 Liver
2 Other
8 NA (not applicable)
9 Unknown


43 MET_SITE_BONE number (1,0) Required:false
Metastatic site: Bone? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


44 MET_SITE_BRAIN number (1,0) Required:false
Metastatic site: Brain/other CNS organ? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


45 MET_SITE_LIVER number (1,0) Required:false
Metastatic site: Liver? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


46 MET_SITE_LUNG number (1,0) Required:false
Metastatic site: Lung/other thoracic organ? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


47 MET_SITE_NODES number (1,0) Required:false
Metastatic site: Distant lymph nodes? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


48 MET_SITE_OVARY number (1,0) Required:false
Metastatic site: Ovary/other gynecologic organ? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


49 MET_SITE_PERITONEAL number (1,0) Required:false
Metastatic site: Peritoneal cavity (includes ascites)? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


50 MET_SITE_SMLBWL number (1,0) Required:false
Metastatic site: Small intestine? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


51 MET_SITE_OTHER number (1,0) Required:false
Metastatic site: Other? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


52 MET_SITE_UNKNOWN number (1,0) Required:false
Metastatic site: Unknown? (Answer if DIST_SPREAD=1).
Allowable Values
1 Yes
2 No
9 Unknown


53 MET_SITE_OTH_TXT string(80) Required:false
Specify other metastatic site. (Answer if MET_SITE_OTHER =1).

54 MET_SITE_SRC number (1,0) Required:false
Source of metastatic site report.
Allowable Values
1 Pathology Report
2 Clinical note
3 Operative note
4 Radiology report
5 Other
9 Unknown


55 pTNM_STAGE number (1,0) Required:true
TNM Stage - Only if reported. Do not derive. Note: Formerly called TNM
Allowable Values
0 in-situ lesions
1 I
2 II
3 III
4 IV
9 Unknown (if DIST_SPREAD scored 9


56 SYNCHRON number (1,0) Required:true
Synchronous colorectal cancer.
Allowable Values
1 Yes
2 No
9 Unknown


57 ADJ_ADEN number (1,0) Required:false
Contiguous (adjacent) adenoma
Allowable Values
1 Yes
2 No
9 Unknown


58 ADJ_ADEN_TYPE number (1,0) Required:false
Type of contiguous (adjacent) adenoma (Answer if ADJ_ADEN=1)
Allowable Values
1 Tubular adenoma (TA)
2 Tubulovillous (TV)
3 Villous adenoma (VA)
4 Traditional serrated adenoma (TSA)
5 Hyperplastic polyp (HP)
6 Other (include mixed)
7 Adenomatous, type unspecified
8 NA (Not applicable) (IF ADJ_ADEN
9 Unknown
10 Sessile serrated polyp / lesion / adenoma (SSP/L/A)


59 ADJ_SIZE number (3,0) Required:false
Size (mm) of contiguous (adjacent) adenoma (Answer if ADJ_ADEN=1)
Allowable Values
0 to 990 or 998, 999 Range
0 No mass (ie. Flat adenoma)
1 Microscopic focus/foci
2 990
998 Not applicable (if ADJ_ADEN
999 Unknown (if ADJ_ADEN


60 ADJ_GRADE number (1,0) Required:false
Grade of contiguous (adjacent) adenoma (Answer if ADJ_ADEN=1)
Allowable Values
1 Mild
2 Moderate
3 Severe/high/in-situ
4 No evidence of dysplasia
8 Not applicable (if ADJ_ADEN
9 Unknown (If ADJ_ADEN