Module: colorectal-path

Module Contents

  1. colorectal-malig
    1.CENTER_NO
    2.PERSON_ID
    3.TUMOR_NO
    4.DT_EVAL
    5.BLOCK_SPEC_CID
    6.SPEC_EXAM
    7.PRIM_SITE_CAT
    8.PRIM_HIST_CAT
    9.GRADE
    10.MARGIN
    11.LC_PERI
    12.LC_CROHN
    13.LC_INFIL
    14.LOC_EXCIS
    15.TSTAGE_M
    16.DIST_SPREAD
    17.LN
    18.LN_POS
    19.LN_EX
    20.VEN_INV
    21.TNM
    22.SYNCHRON
    23.ADJ_ADEN
    24.ADJ_ADEN_TYPE
    25.ADJ_SIZE
    26.ADJ_GRADE
    27.MET_SITE

1 CENTER_NO number (2,0) Required:true
Center identification number.
Allowable Values
11 Sinai Health Systems (formerly Cancer Care Ontario)
12 Cedars-Sinai & Cleveland Clinic (formerly USC Consortium)
13 University of Melbourne
14 University of Hawaii Cancer Center
15 Mayo Clinic
16 Fred Hutch, Seattle
17 UCSF: University of California at San Franscisco (formerly CPIC, originally Northern California (NCCC))


2 PERSON_ID string (12) Required:true
Number that uniquely identifies an individual.

3 TUMOR_NO number (2,0) Required:true
Computer generated sequential number, starting with 1, assigned to each tumor for a given individual when entered into the local system. No adjustment is made when a tumor is deleted from the system. Tumor numbers are never reused. PERSON_NO, TUMOR_NO uniquely identifies each tumor in the CIS. Tumor number should correspond with information from the CANCER file from Volume I.
Allowable Values
1 to 99 Range


4 DT_EVAL string (8) Required:true
Date of this record (i.e. date specimen evaluated).

5 BLOCK_SPEC_CID string (9) Required:false
Specimen ID number. Consists of concatenation of CENTER_NO (2 digit) + local specimen number (7 characters). References TISSUE file from Volume II Biospecimen Data Dictionary. F-121 : SPECIMEN_ID must begin with CENTER_NO (COLORECT_MALIG) F-200 : SPECIMEN_ID must begin with CENTER_NO (POLYPS)

6 SPEC_EXAM number (1,0) Required:true
Was specimen examined from primary site or metastatic site?.
Allowable Values
1 Primary site
2 Metastatic site
3 Both


7 PRIM_SITE_CAT number (1,0) Required:true
Primary site of colorectal cancer; Should include hepatic and splenic flexures with transverse colon.
Allowable Values
1 Caecum
2 Asc
3 Trans
4 Desc
5 Sigmoid
6 Rectum
7 Appendix
9 Unknown


8 PRIM_HIST_CAT number (1,0) Required:true
Categorization of histologic type of colorectal primary site; In mucinous carcinomas at least 50% of the tumor comprises areas in which mucin secretion is abundant (more mucus than epithelium). Most poorly differentiated solid types include areas of adenocarcinoma and should not be called undifferentiated. In signet ring cell cancers, 50% of the tumor is composed of signet ring cells.
Allowable Values
1 Adenocarcinoma
2 Mucinous
3 Signet ring
4 Undiff
5 Other


9 GRADE number (1,0) Required:true
Grade (worst); The worst area should be graded. Minor fragmentation of glands at the growing tumor margin should be ignored. Well-differentiated cancers have well-formed glands relatively uniform nuclear characteristics. There is a resemblance to adenomatous epithelium. Moderately differentiated cancers have irregular glands but a glandular architecture is still obvious. In poorly differentiated cancers glandular architecture is discerned with difficulty. These are well circumscribed with solid sheets and/or trabeculae and/or cribiforing and/or signet ring areas.
Allowable Values
1 Well
2 Moderate
3 Poor
4 Undifferentiated
9 Unknown


10 MARGIN number (1,0) Required:false
Tumor margin; Cancers considered, as intermediate between expanding and infiltrating should be grouped with the expanding subset. An infiltrating growth pattern may be suspected by naked eye examination of the slide because the pink muscle and blue tumor are merged and difficult to distinguish. Microscopically, infiltrating cancers dissect between muscle bundles, often with a ''raining down'' pattern. There is often diffuse infiltration of fat, perineurial invasion and vascular invasion.
Allowable Values
1 Expanding
2 Infiltrating
9 Unknown


11 LC_PERI number (1,0) Required:false
Peritumoral lymphocytes; The presence of peritumoral lymphocytes indicates a distinct inflammatory cuff or cap at the deepest point of penetration of the tumor. The inflammatory cells include neutrophils, eosinophils, macrophages and plasma cells as well as lymphocytes.
Allowable Values
1 Yes
2 No
9 Unknown


12 LC_CROHN number (1,0) Required:false
Crohn''s-like Lymphocytes; The Crohn''s-like reaction refers to lymphocytes arranged in aggregates or nodules, mainly away from the cancer and in the perirectal or mesenteric fat. It is suggested that at least three lymphoid aggregates should be present in a section.
Allowable Values
1 Yes
2 No
9 Unknown


13 LC_INFIL number (1,0) Required:false
Tumor infiltrating lymphocytes. In marked infiltration, the malignant epithelium is peppered with lymphocytes. The ratio of nuclei (lymphocyte:epithelial) should be at least 1:10 (or at least 12 intraepithelial lymphocytes within a high power (40) field) in the most obviously affected areas (about 3% of cases). Mild infiltration means that the lymphocyte: epithelial ratio should be at least 1:25 (or at least 5 unequivocal intraepithelial lymphocytes within one high power (40) field) in the most obviously affected areas (about 17% of cases). None means a lower frequency or none detected after searching for one minute (about 80% if cases).
Allowable Values
1 Yes, marked
2 Yes, mild
3 No
9 Unknown


14 LOC_EXCIS number (1,0) Required:true
Local excision
Allowable Values
1 Complete
2 Incomplete
9 Unknown


15 TSTAGE_M number (1,0) Required:true
T stage of colorectal cancer
Allowable Values
1 to 4 or 8,9 Range
8 Tis (Carcinoma in-situ)
9 Unknown


16 DIST_SPREAD number (1,0) Required:true
Distant spread - colorectal cancer
Allowable Values
1 Yes
2 No
9 Unknown (score unknown if no definitive statement of distant spread in pathology report)


17 LN number (1,0) Required:true
Positive nodes?
Allowable Values
1 Yes
2 No
9 Unknown


18 LN_POS number (2,0) Required:true
Number of positive nodes. Note: codes adopted from SEER & NAACCR standards.
Allowable Values
0 to 99 Range
0 All nodes examined negative
96 96 or more positive nodes
97 Positive nodes, number of positive nodes not specified
98 No nodes examined
99 Unknown if nodes are positive or negative; not applicable


19 LN_EX number (2,0) Required:true
Total number of examined nodes. Note: codes adopted from SEER & NAACCR standards.
Allowable Values
0 to 89 or 90, 95, 96, 99 Range
0 No nodes examined
90 90 or more nodes examined
95 No nodes removed
96 Node sampling; number unknown/not stated
99 Unknown if nodes examined; not applicable


20 VEN_INV number (1,0) Required:false
Venous invasion (note: formerly called vascular invasion VAS_INV).
Allowable Values
1 Yes
2 No
9 Unknown


21 TNM number (1,0) Required:true
TNM Stage
Allowable Values
1 I
2 II
3 III
4 IV
0 in-situ lesions
9 Unknown (if distant spread is scored 9


22 SYNCHRON number (1,0) Required:true
Synchronous colorectal cancer.
Allowable Values
1 Yes
2 No
9 Unknown


23 ADJ_ADEN number (1,0) Required:false
Contiguous (adjacent) adenoma
Allowable Values
1 Yes
2 No
9 Unknown


24 ADJ_ADEN_TYPE number (1,0) Required:false
Type of contiguous (adjacent) adenoma
Allowable Values
1 TA (tubular adenoma)
2 TV (tubulovillous adenoma)
3 VA (villous adenoma)
4 SA (serrated adenoma)
5 HP (hyperplastic polyp)
6 Other (include mixed)
7 Adenomatous, type unspecified
8 NA (Not applicable)
9 Unknown


25 ADJ_SIZE number (3,0) Required:false
Size (mm) of contiguous (adjacent) adenoma
Allowable Values
0 to 990 or 998, 999 Range
0 No mass
1 Microscopic
998 Not applicable
999 Unknown


26 ADJ_GRADE number (1,0) Required:false
Grade of contiguous (adjacent) adenoma
Allowable Values
1 Mild
2 Moderate
3 Severe
8 Not applicable
9 Unknown


27 MET_SITE number (1,0) Required:false
Metastatic site.
Allowable Values
1 Liver
2 Other
8 NA (not applicable)
9 Unknown