Module: colorectal-path

Module Contents

1. colon-clinical-treatment
   1.CENTER_NO
   2.PERSON_ID
   3.CRC_PRIM
   4.CRC1_TUMOR_NO
   5.CRC1_ICD
   6.CRC1_DXDATE
   7.CRC1_SURG
   8.CRC1_SURG_TYPE
   9.CRC1_SURG_TYPE_TXT
   10.CRC1_SURG_DATE
   11.CRC1_SURG_LOCAL
   12.CRC1_SURG_OTHORG
   13.CRC1_SURG_OTHORG_SM_INTEST
   14.CRC1_SURG_OTHORG_LIVER
   15.CRC1_SURG_OTHORG_APPENDIX
   16.CRC1_SURG_OTHORG_OVARY_NOS
   17.CRC1_SURG_OTHORG_OVARY_R
   18.CRC1_SURG_OTHORG_OVARY_L
   19.CRC1_SURG_OTHORG_OVARY_B
   20.CRC1_SURG_OTHORG_SPLEEN
   21.CRC1_SURG_OTHORG_BLADDER
   22.CRC1_SURG_OTHORG_OTH
   23.CRC1_SURG_OTHORG_OTH_TXT
   24.CRC1_SURG_MARGIN
   25.CRC1_MET
   26.CRC1_MET_ASCITES
   27.CRC1_MET_MESEN_LN
   28.CRC1_MET_LIVER
   29.CRC1_MET_LUNG
   30.CRC1_MET_OMENTUM
   31.CRC1_MET_ABD_WALL
   32.CRC1_MET_OVARY
   33.CRC1_MET_BONE
   34.CRC1_MET_PERITO
   35.CRC1_MET_MESEN
   36.CRC1_MET_OTH
   37.CRC1_MET_OTH_TXT
   38.CRC1_MET_RESECT
   39.CRC1_MET_RESECT_DATE
   40.CRC1_T
   41.CRC1_N
   42.CRC1_M
   43.CRC1_T_SRC
   44.CRC1_T_SRC_TXT
   45.CRC1_N_SRC
   46.CRC1_N_SRC_TXT
   47.CRC1_M_SRC
   48.CRC1_M_SRC_TXT
   49.CRC1_CHEMO
   50.CRC1_CHEMO_METHOD
   51.CRC1_CHEMO1_DATE
   52.CRC1_CHEMO1_AGT
   53.CRC1_CHEMO1_AGT_5FU
   54.CRC1_CHEMO1_AGT_FA
   55.CRC1_CHEMO1_AGT_CPT11
   56.CRC1_CHEMO1_AGT_OXAL
   57.CRC1_CHEMO1_AGT_LEVA
   58.CRC1_CHEMO1_AGT_XELO
   59.CRC1_CHEMO1_AGT_AVAS
   60.CRC1_CHEMO1_AGT_ERBI
   61.CRC1_CHEMO1_AGT_GEMZ
   62.CRC1_CHEMO1_AGT_OTH
   63.CRC1_CHEMO1_AGT_OTH_TXT
   64.CRC1_RAD
   65.CRC1_RAD_METHOD
   66.CRC1_RAD1_DATE
   67.CRC1_TREAT_OTH
   68.CRC1_TREAT_OTH_TXT
   69.CRC1_SYNC
   70.CRC1_SYNC_NUM
   71.CRC1_SYNC2_TUMOR_NO
   72.CRC1_SYNC2_ICD
   73.CRC1_SYNC2_DXDATE
   74.CRC1_SYNC2_SURG_TYPE
   75.CRC1_SYNC2_SURG_TYPE_TXT
   76.CRC1_SYNC2_SURG_LOCAL
   77.CRC1_SYNC2_SURG_MARGIN
   78.CRC1_SYNC3_TUMOR_NO
   79.CRC1_SYNC3_ICD
   80.CRC1_SYNC3_DXDATE
   81.CRC1_SYNC3_SURG_TYPE
   82.CRC1_SYNC3_SURG_TYPE_TXT
   83.CRC1_SYNC3_SURG_LOCAL
   84.CRC1_SYNC3_SURG_MARGIN
   85.LR_RECUR
   86.LR1_DATE
   87.LR1_ANAST
   88.LR1_MESEN
   89.LR1_ABD_WALL
   90.LR1_INCS
   91.LR1_PELVIS
   92.LR1_OTH
   93.LR1_OTH_TXT
   94.LR1_TREAT
   95.LR1_SURG
   96.LR1_SURG_LOCAL
   97.LR1_SURG_TXT
   98.LR1_CHEMO
   99.LR1_CHEMO_METHOD
   100.LR1_CHEMO1_DATE
   101.LR1_CHEMO1_AGT
   102.LR1_CHEMO1_AGT_5FU
   103.LR1_CHEMO1_AGT_FA
   104.LR1_CHEMO1_AGT_CPT11
   105.LR1_CHEMO1_AGT_OXAL
   106.LR1_CHEMO1_AGT_LEVA
   107.LR1_CHEMO1_AGT_XELO
   108.LR1_CHEMO1_AGT_AVAS
   109.LR1_CHEMO1_AGT_ERBI
   110.LR1_CHEMO1_AGT_GEMZ
   111.LR1_CHEMO1_AGT_OTH
   112.LR1_CHEMO1_AGT_OTH_TXT
   113.LR1_RAD
   114.LR1_RAD_METHOD
   115.LR1_RAD1_DATE
   116.LR1_TREAT_OTH
   117.LR1_TREAT_OTH_TXT
   118.LR_ADD
   119.LR_ADD_ANAST
   120.LR_ADD_ANAST_DATE
   121.LR_ADD_MESEN
   122.LR_ADD_MESEN_DATE
   123.LR_ADD_ABD_WALL
   124.LR_ADD_ABD_WALL_DATE
   125.LR_ADD_INCS
   126.LR_ADD_INCS_DATE
   127.LR_ADD_PELVIS
   128.LR_ADD_PELVIS_DATE
   129.LR_ADD_OTH
   130.LR_ADD_OTH_TXT
   131.LR_ADD_OTH_DATE
   132.DST_R
   133.DST_R1_DATE
   134.DST_R1_LIVER
   135.DST_R1_LUNG
   136.DST_R1_BONE
   137.DST_R1_ASCITES
   138.DST_R1_NONMES_LN
   139.DST_R1_NONMES_LN_TXT
   140.DST_R1_SUPRA_LN
   141.DST_R1_BRAIN
   142.DST_R1_SKIN
   143.DST_R1_SKIN_TXT
   144.DST_R1_ADRENAL
   145.DST_R1_OTH
   146.DST_R1_OTH_TXT
   147.DST_R1_TREAT
   148.DST_R1_SURG
   149.DST_R1_SURG_LOCAL
   150.DST_R1_SURG_TXT
   151.DST_R1_CHEMO
   152.DST_R1_CHEMO_METHOD
   153.DST_R1_CHEMO1_DATE
   154.DST_R1_CHEMO1_AGT
   155.DST_R1_CHEMO1_AGT_5FU
   156.DST_R1_CHEMO1_AGT_FA
   157.DST_R1_CHEMO1_AGT_CPT11
   158.DST_R1_CHEMO1_AGT_OXAL
   159.DST_R1_CHEMO1_AGT_LEVA
   160.DST_R1_CHEMO1_AGT_XELO
   161.DST_R1_CHEMO1_AGT_AVAS
   162.DST_R1_CHEMO1_AGT_ERBI
   163.DST_R1_CHEMO1_AGT_GEMZ
   164.DST_R1_CHEMO1_AGT_OTH
   165.DST_R1_CHEMO1_AGT_OTH_TXT
   166.DST_R1_RAD
   167.DST_R1_RAD_METHOD
   168.DST_R1_RAD1_DATE
   169.DST_R_ADD
   170.DST_R_ADD_LIVER
   171.DST_R_ADD_LIVER_DATE
   172.DST_R_ADD_LUNG
   173.DST_R_ADD_LUNG_DATE
   174.DST_R_ADD_BONE
   175.DST_R_ADD_BONE_DATE
   176.DST_R_ADD_ASCITES
   177.DST_R_ADD_ASCITES_DATE
   178.DST_R_ADD_NONMES_LN
   179.DST_R_ADD_NONMES_LN_DATE
   180.DST_R_ADD_NONMES_LN_TXT
   181.DST_R_ADD_SUPRA_LN
   182.DST_R_ADD_SUPRA_LN_DATE
   183.DST_R_ADD_BRAIN
   184.DST_R_ADD_BRAIN_DATE
   185.DST_R_ADD_SKIN
   186.DST_R_ADD_SKIN_DATE
   187.DST_R_ADD_SKIN_TXT
   188.DST_R_ADD_ADRENAL
   189.DST_R_ADD_ADRENAL_DATE
   190.DST_R_ADD_OTH
   191.DST_R_ADD_OTH_DATE
   192.DST_R_ADD_OTH_TXT
   193.NEW_CRC_PRIM
   194.NEW_CRC1_TUMOR_NO
   195.NEW_CRC1_ICD
   196.NEW_CRC1_DXDATE
   197.NEW_CRC1_SURG
   198.NEW_CRC1_SURG_TYPE
   199.NEW_CRC1_SURG_TYPE_TXT
   200.NEW_CRC1_SURG_DATE
   201.NEW_CRC1_SURG_LOCAL
   202.NEW_CRC1_SURG_OTHORG
   203.NEW_CRC1_SURG_OTHORG_SM_INTEST
   204.NEW_CRC1_SURG_OTHORG_LIVER
   205.NEW_CRC1_SURG_OTHORG_APPENDIX
   206.NEW_CRC1_SURG_OTHORG_OVARY_NOS
   207.NEW_CRC1_SURG_OTHORG_OVARY_R
   208.NEW_CRC1_SURG_OTHORG_OVARY_L
   209.NEW_CRC1_SURG_OTHORG_OVARY_B
   210.NEW_CRC1_SURG_OTHORG_SPLEEN
   211.NEW_CRC1_SURG_OTHORG_BLADDER
   212.NEW_CRC1_SURG_OTHORG_OTH
   213.NEW_CRC1_SURG_OTHORG_OTH_TXT
   214.NEW_CRC1_SURG_MARGIN
   215.NEW_CRC1_MET
   216.NEW_CRC1_MET_ASCITES
   217.NEW_CRC1_MET_MESEN_LN
   218.NEW_CRC1_MET_LIVER
   219.NEW_CRC1_MET_LUNG
   220.NEW_CRC1_MET_OMENTUM
   221.NEW_CRC1_MET_ABD_WALL
   222.NEW_CRC1_MET_OVARY
   223.NEW_CRC1_MET_BONE
   224.NEW_CRC1_MET_PERITO
   225.NEW_CRC1_MET_MESEN
   226.NEW_CRC1_MET_OTH
   227.NEW_CRC1_MET_OTH_TXT
   228.NEW_CRC1_MET_RESECT
   229.NEW_CRC1_MET_RESECT_DATE
   230.NEW_CRC1_T
   231.NEW_CRC1_N
   232.NEW_CRC1_M
   233.NEW_CRC1_T_SRC
   234.NEW_CRC1_T_SRC_TXT
   235.NEW_CRC1_N_SRC
   236.NEW_CRC1_N_SRC_TXT
   237.NEW_CRC1_M_SRC
   238.NEW_CRC1_M_SRC_TXT
   239.NEW_CRC1_CHEMO
   240.NEW_CRC1_CHEMO_METHOD
   241.NEW_CRC1_CHEMO1_DATE
   242.NEW_CRC1_CHEMO1_AGT
   243.NEW_CRC1_CHEMO1_AGT_5FU
   244.NEW_CRC1_CHEMO1_AGT_FA
   245.NEW_CRC1_CHEMO1_AGT_CPT11
   246.NEW_CRC1_CHEMO1_AGT_OXAL
   247.NEW_CRC1_CHEMO1_AGT_LEVA
   248.NEW_CRC1_CHEMO1_AGT_XELO
   249.NEW_CRC1_CHEMO1_AGT_AVAS
   250.NEW_CRC1_CHEMO1_AGT_ERBI
   251.NEW_CRC1_CHEMO1_AGT_GEMZ
   252.NEW_CRC1_CHEMO1_AGT_OTH
   253.NEW_CRC1_CHEMO1_AGT_OTH_TXT
   254.NEW_CRC1_RAD
   255.NEW_CRC1_RAD_METHOD
   256.NEW_CRC1_RAD1_DATE
   257.NEW_CRC1_TREAT_OTH
   258.NEW_CRC1_TREAT_OTH_TXT
   259.NEW_CRC1_SYNC
   260.NEW_CRC1_SYNC_NUM
   261.NEW_CRC1_SYNC2_TUMOR_NO
   262.NEW_CRC1_SYNC2_ICD
   263.NEW_CRC1_SYNC2_DXDATE
   264.NEW_CRC1_SYNC2_SURG_TYPE
   265.NEW_CRC1_SYNC2_SURG_TYPE_TXT
   266.NEW_CRC1_SYNC2_SURG_LOCAL
   267.NEW_CRC1_SYNC2_SURG_MARGIN
   268.NEW_CRC1_SYNC3_TUMOR_NO
   269.NEW_CRC1_SYNC3_ICD
   270.NEW_CRC1_SYNC3_DXDATE
   271.NEW_CRC1_SYNC3_SURG_TYPE
   272.NEW_CRC1_SYNC3_SURG_TYPE_TXT
   273.NEW_CRC1_SYNC3_SURG_LOCAL
   274.NEW_CRC1_SYNC3_SURG_MARGIN
   275.NEW_CRC2_PRIM
   276.NEW_CRC2_TUMOR_NO
   277.NEW_CRC2_ICD
   278.NEW_CRC2_DXDATE
   279.NEW_CRC2_SURG_TYPE
   280.NEW_CRC2_SURG_TYPE_TXT
   281.NEW_CRC2_SURG_TYPE_LOCAL
   282.NEW_CRC2_SURG_TYPE_MARGIN
   283.NEW_CRC2_SYNC
   284.NEW_CRC2_SYNC_NUM
   285.NEW_NONCRC_PRIM
   286.NEW_NONCRC1_ICD
   287.NEW_NONCRC2_ICD
   288.NEW_NONCRC3_ICD
   289.LAST_STATUS
   290.DEATH_DATE
   291.DEATH_CAUSE
   292.LAST_CHART_DATE
   293.COMPLETE_DATE
   294.LR_DST_RECUR
   295.LR_DST1_ANAST
   296.LR_DST1_ANAST_DATE
   297.LR_DST1_MESEN
   298.LR_DST1_MESEN_DATE
   299.LR_DST1_ABD_WALL
   300.LR_DST1_ABD_WALL_DATE
   301.LR_DST1_INCS
   302.LR_DST1_INCS_DATE
   303.LR_DST1_PELVIS
   304.LR_DST1_PELVIS_DATE
   305.LR_DST1_LIVER
   306.LR_DST1_LIVER_DATE
   307.LR_DST1_LUNG
   308.LR_DST1_LUNG_DATE
   309.LR_DST1_BONE
   310.LR_DST1_BONE_DATE
   311.LR_DST1_ASCITES
   312.LR_DST1_ASCITES_DATE
   313.LR_DST1_NONMES_LN
   314.LR_DST1_NONMES_LN_DATE
   315.LR_DST1_NONMES_LN_TXT
   316.LR_DST1_SUPRA_LN
   317.LR_DST1_SUPRA_LN_DATE
   318.LR_DST1_BRAIN
   319.LR_DST1_BRAIN_DATE
   320.LR_DST1_SKIN
   321.LR_DST1_SKIN_DATE
   322.LR_DST1_SKIN_TXT
   323.LR_DST1_ADRENAL
   324.LR_DST1_ADRENAL_DATE
   325.LR_DST1_OTH
   326.LR_DST1_OTH_TXT
   327.LR_DST1_OTH_DATE

1	CENTER_NO	number (2,0)	Required:true
	Center identification number.
Allowable Values 11 Sinai Health Systems (formerly Cancer Care Ontario) 12 Cedars-Sinai & Cleveland Clinic (formerly USC Consortium) 13 University of Melbourne 14 University of Hawaii Cancer Center 15 Mayo Clinic 16 Fred Hutch, Seattle 17 UCSF: University of California at San Franscisco (formerly CPIC, originally Northern California (NCCC))

2	PERSON_ID	string (12)	Required:true
	Number that uniquely identifies an individual.

3	CRC_PRIM	number (1,0)	Required:true
	Primary CRC cancer diagnosed
Allowable Values 1 Yes 2 No

4	CRC1_TUMOR_NO	number (2,0)	Required:true
	PERSON_NO, TUMOR_NO uniquely identifies each tumor in the Informatics Centre. Tumor number should correspond with information from the CANCER file

5	CRC1_ICD	string (7)	Required:false
	ICD CODE: ICD0 code

6	CRC1_DXDATE	string (8)	Required:false
	Diagnosis Date Of First CRC Primary(s) in the Eligibility Period:
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

7	CRC1_SURG	number (1,0)	Required:false
	Surgical treatment performed
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

8	CRC1_SURG_TYPE	number (2,0)	Required:false
	Type of surgical treatment (Can use SEER coding to derive)
Allowable Values 2 Local tumor destruction, i.e. laser, electrocautery 3 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 4 Right Hemi colectomy 5 Left Hemi colectomy 6 Hemi colectomy side not specified: not total 7 Low Anterior resection 8 Total Colectomy 9 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other Surgery

9	CRC1_SURG_TYPE_TXT	string (250)	Required:false
	Free text describing other surgery

10	CRC1_SURG_DATE	string (8)	Required:false
	Date of 1st resection:
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

11	CRC1_SURG_LOCAL	number (1,0)	Required:false
	Operative findings indicating completeness of excision: (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not asked. 9 Unknown

12	CRC1_SURG_OTHORG	number (1,0)	Required:false
	Were other organs (partial or total) removed at definitive surgery?
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

13	CRC1_SURG_OTHORG_SM_INTEST	number (1,0)	Required:false
	If small intestine (partial or total) were removed, please specify:
Allowable Values 1 yes 2 not reported

14	CRC1_SURG_OTHORG_LIVER	number (1,0)	Required:false
	If liver (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

15	CRC1_SURG_OTHORG_APPENDIX	number (1,0)	Required:false
	If appendix (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

16	CRC1_SURG_OTHORG_OVARY_NOS	number (1,0)	Required:false
	If ovary (partial or total) were removed and no information on which side (left or right) , please specify:
Allowable Values 1 yes 2 not reported

17	CRC1_SURG_OTHORG_OVARY_R	number (1,0)	Required:false
	If right ovary (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

18	CRC1_SURG_OTHORG_OVARY_L	number (1,0)	Required:false
	If left ovary (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

19	CRC1_SURG_OTHORG_OVARY_B	number (1,0)	Required:false
	If both ovaries (partial or total) were removed, please specify:
Allowable Values 1 yes 2 not reported

20	CRC1_SURG_OTHORG_SPLEEN	number (1,0)	Required:false
	If spleen (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

21	CRC1_SURG_OTHORG_BLADDER	number (1,0)	Required:false
	If bladder (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

22	CRC1_SURG_OTHORG_OTH	number (1,0)	Required:false
	If other organs (partial or total) were removed, please specify:
Allowable Values 1 yes 2 not reported

23	CRC1_SURG_OTHORG_OTH_TXT	string (250)	Required:false
	Free text describing other organs (partial or total) that were removed if more than one separate with commas

24	CRC1_SURG_MARGIN	number (1,0)	Required:false
	Did the tumor reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

25	CRC1_MET	number (1,0)	Required:false
	Metastatic Disease Found at the time of surgery (from perative report)
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

26	CRC1_MET_ASCITES	number (1,0)	Required:false
	Site of Metastatic Disease: ASCITES
Allowable Values 1 yes 2 not reported

27	CRC1_MET_MESEN_LN	number (1,0)	Required:false
	Site of Metastatic Disease: Mesenteric lymph nodes, other than in mesentery of planned resection
Allowable Values 1 yes 2 not reported

28	CRC1_MET_LIVER	number (1,0)	Required:false
	Site of Metastatic Disease: Liver
Allowable Values 1 yes 2 not reported

29	CRC1_MET_LUNG	number (1,0)	Required:false
	Site of Metastatic Disease: Lung
Allowable Values 1 yes 2 not reported

30	CRC1_MET_OMENTUM	number (1,0)	Required:false
	Site of Metastatic Disease: Omentum
Allowable Values 1 yes 2 not reported

31	CRC1_MET_ABD_WALL	number (1,0)	Required:false
	Site of Metastatic Disease: Abdominal wall
Allowable Values 1 yes 2 not reported

32	CRC1_MET_OVARY	number (1,0)	Required:false
	Site of Metastatic Disease: Ovary(s)
Allowable Values 1 yes 2 not reported

33	CRC1_MET_BONE	number (1,0)	Required:false
	Site of Metastatic Disease: Bone
Allowable Values 1 yes 2 not reported

34	CRC1_MET_PERITO	number (1,0)	Required:false
	Site of Metastatic Disease: Peritoneum
Allowable Values 1 yes 2 not reported

35	CRC1_MET_MESEN	number (1,0)	Required:false
	Site of Metastatic Disease: Mesentery
Allowable Values 1 yes 2 not reported

36	CRC1_MET_OTH	number (1,0)	Required:false
	Site of Metastatic Disease: Other
Allowable Values 1 yes 2 not reported

37	CRC1_MET_OTH_TXT	string (250)	Required:false
	Free text describing other site of Metastatic Disease. If more than one separate with commas.

38	CRC1_MET_RESECT	number (1,0)	Required:false
	Was this metastasis resected immediately (within 3 months) after baseline surgery)
Allowable Values 1 All metastases entirely resected 2 At least one metastasis not entirely resected 3 Not resected (No surgery) 8 Not Asked 9 Unknown

39	CRC1_MET_RESECT_DATE	string (8)	Required:false
	Date metastasis was resected (only if metastasis was completely or incompletely resected) Month of metastasis resection: Day of metastasis resection: Year of metastasis resection:
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

40	CRC1_T	number (1,0)	Required:false
	Tumor Stage at Baseline (0-4)
Allowable Values 0 Carcinoma in situ/TIS 1 Tumor invades submucosa 2 Tumor invades muscularis propria 3 Tumor invades through muscularis propria into submucosa or into non peritonealized pericolic or perirectal tissues 4 Tumor directly invades other organs/structures/perforates visceral peritonium 8 Not Asked 9 Unknown

41	CRC1_N	number (1,0)	Required:false
	Nodal stage at Baseline (0-3)
Allowable Values 0 No regional lymph node metastasis 1 Metastasis in 1 to 3 regional lymph nodes 2 Metastasis in 4 or more regional lymph nodes 8 Not Asked 9 Unknown

42	CRC1_M	number (1,0)	Required:false
	Metastasis stage at Baseline (0-1)
Allowable Values 0 No distant metastasis 1 Distant metastasis is present 8 Not Asked 9 Unknown

43	CRC1_T_SRC	number (1,0)	Required:false
	Source of information for tumor stage:
Allowable Values 1 Pathology Report 2 Clinic Note/Discharge Summary 3 Other (Specify): 8 Not Asked 9 Unknown

44	CRC1_T_SRC_TXT	string (250)	Required:false
	Source of information for tumor stage: OTHER

45	CRC1_N_SRC	number (1,0)	Required:false
	Source of information for nodal stage:
Allowable Values 1 Pathology Report 2 Clinic Note/Discharge Summary 3 Other (Specify): 8 Not Asked 9 Unknown

46	CRC1_N_SRC_TXT	string (250)	Required:false
	Source of information for nodal stage: OTHER

47	CRC1_M_SRC	number (1,0)	Required:false
	Source of information for metastasis stage):
Allowable Values 1 Pathology Report 2 Clinic Note/Discharge Summary 3 Operative Note 4 Radiology report (US, CT, MRI etc.) 5 Other (Specify): 8 Not Asked 9 Unknown

48	CRC1_M_SRC_TXT	string (250)	Required:false
	Source of information for metastasis stage):-OTHER

49	CRC1_CHEMO	number (1,0)	Required:false
	Was chemotherapy given for treatment of the primary colorectal cancer(s)?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

50	CRC1_CHEMO_METHOD	number (1,0)	Required:false
	What method of chemotherapy was applied for treatment of the primary colorectal cancer(s)? Note: Multiple methods and agents are possible. If so they should be recorded in order given ie Neo Adjuvant first > Adjuvant > Palliative last
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

51	CRC1_CHEMO1_DATE	string (8)	Required:false
	Date of 1st chemotherapy treatment of the CRC primary(s) in the eligibility period
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

52	CRC1_CHEMO1_AGT	number (1,0)	Required:false
	Pseudo gateway question to capture overall "missing/unknown agent"
Allowable Values 1 specified 8 missing 9 unknown

53	CRC1_CHEMO1_AGT_5FU	number (1,0)	Required:false
	5 FU / FLUOROURACIL/ ADRUCIL CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS first course only. Does not include medications given to control or suppress side effect. Also the list is abbreviated and another variable "other" added to list additional drugs
Allowable Values 1 yes 2 not reported

54	CRC1_CHEMO1_AGT_FA	number (1,0)	Required:false
	FA (FOLINIC ACID) / LEUCOVORIN / WELLCOVORIN CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

55	CRC1_CHEMO1_AGT_CPT11	number (1,0)	Required:false
	CPT11/ IRINOTECAN / CAMPTOSAR CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

56	CRC1_CHEMO1_AGT_OXAL	number (1,0)	Required:false
	OXALIPLATIN / ELOXATIN CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

57	CRC1_CHEMO1_AGT_LEVA	number (1,0)	Required:false
	LEVAMISOLE CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

58	CRC1_CHEMO1_AGT_XELO	number (1,0)	Required:false
	XELODA / CAPECITABINE CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

59	CRC1_CHEMO1_AGT_AVAS	number (1,0)	Required:false
	AVASTIN / BEVACIZUMAB CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

60	CRC1_CHEMO1_AGT_ERBI	number (1,0)	Required:false
	ERBITUX/ CETUXIMAB CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

61	CRC1_CHEMO1_AGT_GEMZ	number (1,0)	Required:false
	GEMZAR CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

62	CRC1_CHEMO1_AGT_OTH	number (1,0)	Required:false
	OTHER AGENT CHEMOTHERAPEUTIC AGENT FOR BASELINE DIAGNOSIS
Allowable Values 1 yes 2 not reported

63	CRC1_CHEMO1_AGT_OTH_TXT	string (250)	Required:false
	NAME of OTHER AGENT, If more than one separate with commas.

64	CRC1_RAD	number (1,0)	Required:false
	Was radiation given for treatment of the primary colorectal cancer(s)?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

65	CRC1_RAD_METHOD	number (1,0)	Required:false
	What method of radiotherapy was applied for treatment of the primary colorectal cancer(s)?
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

66	CRC1_RAD1_DATE	string (8)	Required:false
	Date of 1st radiotherapy treatment of the CRC primary(s) in the eligibility period
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

67	CRC1_TREAT_OTH	number (1,0)	Required:false
	Were other treatment methods applied for primary colorectal cancer(s)?
Allowable Values 1 Yes only one other treatment 2 Yes only 2 other treatments 3 No 8 Not Asked 9 Unknown

68	CRC1_TREAT_OTH_TXT	string (250)	Required:false
	Free text describing 1st other treatment. If more than one separate with commas.

69	CRC1_SYNC	number (1,0)	Required:false
	Were synchronous CRC primaries diagnosed at baseline?
Allowable Values 1 Yes 2 No

70	CRC1_SYNC_NUM	number (2,0)	Required:false
	#_____ of SYNCHRONOUS PRIMARY(S)
Allowable Values 1 to 8 or 88, 99 Range 88 Not asked 99 unknown

71	CRC1_SYNC2_TUMOR_NO	number (2,0)	Required:true
	Tumor number should correspond with information from the CANCER file

72	CRC1_SYNC2_ICD	string (7)	Required:false
	ICD CODE of 2nd largest SYNCHRONOUS CRC PRIMARY (PRIMARY_2) :

73	CRC1_SYNC2_DXDATE	string (8)	Required:false
	DIAGNOSIS DATE OF 2nd SYNCHRONOUS CRC PRIMARY IN THE ELIGIBILITY PERIOD
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

74	CRC1_SYNC2_SURG_TYPE	number (2,0)	Required:false
	Surgical treatment for 2nd synchronous primary CRC (Can use SEER coding to derive)
Allowable Values 1 No Surgery 2 Local tumor destruction, i.e. laser, electrocautery 3 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 4 Right Hemi colectomy 5 Left Hemi colectomy 6 Hemi colectomy Side not specified: not total 7 Low Anterior resection 8 Total Colectomy 9 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other (Specify): 88 Not Asked 99 Unknown

75	CRC1_SYNC2_SURG_TYPE_TXT	string (250)	Required:false
	Surgical treatment for 2nd synchronous primary CRC (Can use SEER coding to derive) OTHER

76	CRC1_SYNC2_SURG_LOCAL	number (1,0)	Required:false
	Operative findings , local (residual tumor) for 2nd synchronous primary CRC (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not Asked 9 Unknown

77	CRC1_SYNC2_SURG_MARGIN	number (1,0)	Required:false
	Did the 2nd synchronous primary CRC reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

78	CRC1_SYNC3_TUMOR_NO	number (2,0)	Required:true
	Tumor number should correspond with information from the CANCER file

79	CRC1_SYNC3_ICD	string (7)	Required:false
	ICD code for 3rd largest SYNCHRONOUS CRC PRIMARY (PRIMARY_3)

80	CRC1_SYNC3_DXDATE	string (8)	Required:false
	DIAGNOSIS DATE OF 3rd SYNCHRONOUS CRC PRIMARY IN THE ELIGIBILITY PERIOD
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

81	CRC1_SYNC3_SURG_TYPE	number (2,0)	Required:false
	Surgical treatment for 3rd synchronous primary CRC (Can use SEER coding to derive)
Allowable Values 01 No Surgery (go to section 3) 02 Local tumor destruction, i.e. laser, electrocautery 03 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 04 Right Hemi colectomy 05 Left Hemi colectomy 06 Hemi colectomy Side not specified: not total 07 Low Anterior resection 08 Total Colectomy 09 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other (Specify): 88 Not Asked 99 Unknown

82	CRC1_SYNC3_SURG_TYPE_TXT	string (250)	Required:false
	Surgical treatment for 3rd synchronous primary CRC (Can use SEER coding to derive) OTHER

83	CRC1_SYNC3_SURG_LOCAL	number (1,0)	Required:false
	Operative findings , local (residual tumor) for 3rd synchronous primary CRC (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not Asked 9 Unknown

84	CRC1_SYNC3_SURG_MARGIN	number (1,0)	Required:false
	Did the 3rd synchronous primary CRC reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

85	LR_RECUR	number (1,0)	Required:true
	Did the patient have at least one locoregional recurrence after CRC diagnosis? (Ideally interval between diagnosis date and final chart review date should be at least 4 years)
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

86	LR1_DATE	string (8)	Required:false
	Date of 1st locoregional recurrence
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

87	LR1_ANAST	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Anastomosis:
Allowable Values 1 yes 2 not reported

88	LR1_MESEN	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Mesentery
Allowable Values 1 yes 2 not reported

89	LR1_ABD_WALL	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Abdominal Wall (not incisional)
Allowable Values 1 yes 2 not reported

90	LR1_INCS	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Incisional
Allowable Values 1 yes 2 not reported

91	LR1_PELVIS	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Pelvi
Allowable Values 1 yes 2 not reported

92	LR1_OTH	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): OTHER
Allowable Values 1 yes 2 not reported

93	LR1_OTH_TXT	string (250)	Required:false
	LocoRegional Recurrence 1st other site Comma separated list of other site(s)

94	LR1_TREAT	number (1,0)	Required:false
	Did patient receive treatment for locoregional recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

95	LR1_SURG	number (1,0)	Required:false
	Surgical treatment given for locoregional recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

96	LR1_SURG_LOCAL	number (1,0)	Required:false
	Surgery for locoregional recurrence:
Allowable Values 1 Recurrent tumor entirely resected 2 Recurrent tumor not entirely resected 8 Not Asked 9 Unknown

97	LR1_SURG_TXT	string (250)	Required:false
	If Surgery for locoregional recurrence: 1 or 2, then specify (describe procedure??text format)

98	LR1_CHEMO	number (1,0)	Required:false
	Was chemotherapy given for locoregional recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

99	LR1_CHEMO_METHOD	number (1,0)	Required:false
	What method of chemotherapy was applied for treatment of the locoregional recurrence(s) Note: Multiple methods and agents are possible. If so they should be recorded in order given ie Neo Adjuvant first > Adjuvant > Palliative last
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

100	LR1_CHEMO1_DATE	string (8)	Required:false
	Date of 1st chemotherapy treatment of the locoregional recurrence.
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

101	LR1_CHEMO1_AGT	number (1,0)	Required:false
	Pseudo gateway question to capture overall "missing/unknown agent"
Allowable Values 1 specified 8 Not Asked 9 Unknown

102	LR1_CHEMO1_AGT_5FU	number (1,0)	Required:false
	5 FU / FLUOROURACIL/ ADRUCIL CHEMOTHERAPEUTIC AGENT first course only. Does not include medications given to control or suppress side effect. Also the list is abbreviated and another variable "other" added to list additional drugs
Allowable Values 1 yes 2 not reported

103	LR1_CHEMO1_AGT_FA	number (1,0)	Required:false
	FA (FOLINIC ACID) / LEUCOVORIN / WELLCOVORIN
Allowable Values 1 yes 2 not reported

104	LR1_CHEMO1_AGT_CPT11	number (1,0)	Required:false
	CPT11/ IRINOTECAN / CAMPTOSAR
Allowable Values 1 yes 2 not reported

105	LR1_CHEMO1_AGT_OXAL	number (1,0)	Required:false
	OXALIPLATIN / ELOXATIN
Allowable Values 1 yes 2 not reported

106	LR1_CHEMO1_AGT_LEVA	number (1,0)	Required:false
	LEVAMISOLE
Allowable Values 1 yes 2 not reported

107	LR1_CHEMO1_AGT_XELO	number (1,0)	Required:false
	XELODA / CAPECITABINE
Allowable Values 1 yes 2 not reported

108	LR1_CHEMO1_AGT_AVAS	number (1,0)	Required:false
	AVASTIN / BEVACIZUMAB
Allowable Values 1 yes 2 not reported

109	LR1_CHEMO1_AGT_ERBI	number (1,0)	Required:false
	ERBITUX/ CETUXIMAB
Allowable Values 1 yes 2 not reported

110	LR1_CHEMO1_AGT_GEMZ	number (1,0)	Required:false
	GEMZAR
Allowable Values 1 yes 2 not reported

111	LR1_CHEMO1_AGT_OTH	number (1,0)	Required:false
	OTHER AGENT CHEMOTHERAPEUTIC AGENT
Allowable Values 1 yes 2 not reported

112	LR1_CHEMO1_AGT_OTH_TXT	string (250)	Required:false
	Free text describing OTHER CHEMOTHERAPEUTIC AGENT for first locoregional recurrence diagnosis. If more than one separate with commas.

113	LR1_RAD	number (1,0)	Required:false
	Was radiotherapy given for locoregional recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

114	LR1_RAD_METHOD	number (1,0)	Required:false
	What method of radiotherapy was applied for treatment of the locoregional recurrence?
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

115	LR1_RAD1_DATE	string (8)	Required:false
	Date of 1st radiotherapy treatment of the locoregional recurrence.
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

116	LR1_TREAT_OTH	number (1,0)	Required:false
	Were other treatment methods applied for first locoregional recurrence?
Allowable Values 1 Yes 1 other treatment 2 Yes 2 other treatments 3 No 8 Not Asked 9 Unknown

117	LR1_TREAT_OTH_TXT	string (250)	Required:false
	Free text describing first other treatment methods applied for first locoregional recurrence. Comma separated list of other agents(s

118	LR_ADD	number (1,0)	Required:false
	Pseudo entry question to section on additional LR sites, ie should be yes if any LR_ADD below are yes.
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

119	LR_ADD_ANAST	number (1,0)	Required:false
	Locoregional recurrence site(s) after the 1st site(s) identified Anastomosis:
Allowable Values 1 yes 2 not reported

120	LR_ADD_ANAST_DATE	string (8)	Required:false
	Diagnosed Month Diagnosed Day (optional) Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

121	LR_ADD_MESEN	number (1,0)	Required:false
	Locoregional recurrence site(s) after the 1st site(s) identified Mesentery
Allowable Values 1 yes 2 not reported

122	LR_ADD_MESEN_DATE	string (8)	Required:false
	Diagnosed Month Diagnosed Day (optional) Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

123	LR_ADD_ABD_WALL	number (1,0)	Required:false
	Locoregional recurrence site(s) after the 1st site(s) identified Abdominal Wall (not incisional)
Allowable Values 1 yes 2 not reported

124	LR_ADD_ABD_WALL_DATE	string (8)	Required:false
	Diagnosed Month Diagnosed Day (optional) Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

125	LR_ADD_INCS	number (1,0)	Required:false
	Locoregional recurrence site(s) after the 1st site(s) identified Incisional
Allowable Values 1 yes 2 not reported

126	LR_ADD_INCS_DATE	string (8)	Required:false
	Diagnosed Month Diagnosed Day (optional) Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

127	LR_ADD_PELVIS	number (1,0)	Required:false
	Locoregional recurrence site(s) after the 1st site(s) identified Pelvis
Allowable Values 1 yes 2 not reported

128	LR_ADD_PELVIS_DATE	string (8)	Required:false
	Diagnosed Month Diagnosed Day (optional) Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

129	LR_ADD_OTH	number (1,0)	Required:false
	Locoregional recurrence site(s) after the 1st site(s) identified Other
Allowable Values 1 yes 2 not reported

130	LR_ADD_OTH_TXT	string (250)	Required:false
	Free text describing additional LR site

131	LR_ADD_OTH_DATE	string (8)	Required:false
	Diagnosed Month Diagnosed Day (optional) Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

132	DST_R	number (1,0)	Required:true
	Did the patient have a distant recurrence after CRC diagnosis (after start date to final chart date available)?
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

133	DST_R1_DATE	string (8)	Required:false
	Date of first distant recurrence
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

134	DST_R1_LIVER	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Liver
Allowable Values 1 yes 2 not reported

135	DST_R1_LUNG	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Lung
Allowable Values 1 yes 2 not reported

136	DST_R1_BONE	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Bone
Allowable Values 1 yes 2 not reported

137	DST_R1_ASCITES	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Ascites
Allowable Values 1 yes 2 not reported

138	DST_R1_NONMES_LN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Non mesenteric lymph nodes (except supraclavicular)
Allowable Values 1 yes 2 not reported

139	DST_R1_NONMES_LN_TXT	string (250)	Required:false
	Free text describing specific non mesenteric lymph nodes (except supraclavicular)

140	DST_R1_SUPRA_LN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Supraclavicular nodes
Allowable Values 1 yes 2 not reported

141	DST_R1_BRAIN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Brain
Allowable Values 1 yes 2 not reported

142	DST_R1_SKIN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence: Skin, except incision Specify site (text):
Allowable Values 1 yes 2 not reported

143	DST_R1_SKIN_TXT	string (250)	Required:false
	Free text describing specific skin site of first distant recurrence
Allowable Values 1 yes 2 not reported

144	DST_R1_ADRENAL	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence: Adrenal gland
Allowable Values 1 yes 2 not reported

145	DST_R1_OTH	number (1,0)	Required:false
	Site(s) of involvement at time of first distant recurrence Other Specify site (text):
Allowable Values 1 yes 2 not reported

146	DST_R1_OTH_TXT	string (250)	Required:false
	Free text describing other site of first distant recurrence

147	DST_R1_TREAT	number (1,0)	Required:false
	Did the patient undergo treatment for distant recurrence?:
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

148	DST_R1_SURG	number (1,0)	Required:false
	Did patient undergo surgical treatment for distant recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

149	DST_R1_SURG_LOCAL	number (1,0)	Required:false
	Surgery for distant recurrence
Allowable Values 1 Recurrent tumor entirely resected 2 Recurrent tumor not entirely resected 8 Not Asked 9 Unknown

150	DST_R1_SURG_TXT	string (250)	Required:false
	Free text describing other surgery for distant recurrence 1 or 2

151	DST_R1_CHEMO	number (1,0)	Required:false
	Did patient undergo chemotherapy for distant recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

152	DST_R1_CHEMO_METHOD	number (1,0)	Required:false
	If chemotherapy was given, what method of chemotherapy was applied for treatment of the distant recurrence? Note: Multiple methods and agents are possible. If so they should be recorded in order given ie Neo Adjuvant first > Adjuvant > Palliative last
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo adjuvant (pre operative) 8 Not Asked 9 Unknown

153	DST_R1_CHEMO1_DATE	string (8)	Required:false
	Date of 1st chemotherapy treatment of the distant recurrence.
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

154	DST_R1_CHEMO1_AGT	number (1,0)	Required:false
	Pseudo gateway question to capture overall "missing/unknown agent
Allowable Values 1 specified 8 Not Asked 9 Unknown

155	DST_R1_CHEMO1_AGT_5FU	number (1,0)	Required:false
	5 FU / FLUOROURACIL/ ADRUCIL CHEMOTHERAPEUTIC AGENT first course only. Does not include medications given to control or suppress side effect. Also the list is abbreviated and another variable "other" added to list additional drugs
Allowable Values 1 yes 2 not reported

156	DST_R1_CHEMO1_AGT_FA	number (1,0)	Required:false
	FA (FOLINIC ACID) / LEUCOVORIN / WELLCOVORIN
Allowable Values 1 yes 2 not reported

157	DST_R1_CHEMO1_AGT_CPT11	number (1,0)	Required:false
	CPT11/ IRINOTECAN / CAMPTOSAR
Allowable Values 1 yes 2 not reported

158	DST_R1_CHEMO1_AGT_OXAL	number (1,0)	Required:false
	OXALIPLATIN / ELOXATIN
Allowable Values 1 yes 2 not reported

159	DST_R1_CHEMO1_AGT_LEVA	number (1,0)	Required:false
	LEVAMISOLE
Allowable Values 1 yes 2 not reported

160	DST_R1_CHEMO1_AGT_XELO	number (1,0)	Required:false
	XELODA / CAPECITABINE
Allowable Values 1 yes 2 not reported

161	DST_R1_CHEMO1_AGT_AVAS	number (1,0)	Required:false
	AVASTIN / BEVACIZUMAB
Allowable Values 1 yes 2 not reported

162	DST_R1_CHEMO1_AGT_ERBI	number (1,0)	Required:false
	ERBITUX/ CETUXIMAB
Allowable Values 1 yes 2 not reported

163	DST_R1_CHEMO1_AGT_GEMZ	number (1,0)	Required:false
	GEMZAR
Allowable Values 1 yes 2 not reported

164	DST_R1_CHEMO1_AGT_OTH	number (1,0)	Required:false
	OTHER AGENT CHEMOTHERAPEUTIC AGENT
Allowable Values 1 yes 2 not reported

165	DST_R1_CHEMO1_AGT_OTH_TXT	string (250)	Required:false
	Free text describing OTHER CHEMOTHERAPEUTIC AGENT for distant recurrence diagnosis. If more than one separate with commas.

166	DST_R1_RAD	number (1,0)	Required:false
	Was radiotherapy treatment given for distant recurrence?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

167	DST_R1_RAD_METHOD	number (1,0)	Required:false
	What method of radiotherapy was applied for treatment of the 1st distant recurrence?
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

168	DST_R1_RAD1_DATE	string (8)	Required:false
	Date of 1st radiotherapy treatment of the distant recurrence.
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

169	DST_R_ADD	number (1,0)	Required:false
	pseudo gateway for additional distant recurrence site(s)
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

170	DST_R_ADD_LIVER	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Liver
Allowable Values 1 yes 2 not reported

171	DST_R_ADD_LIVER_DATE	string (8)	Required:false
	Additional Distant Recurrence First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

172	DST_R_ADD_LUNG	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Lung
Allowable Values 1 yes 2 not reported

173	DST_R_ADD_LUNG_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

174	DST_R_ADD_BONE	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Bone
Allowable Values 1 yes 2 not reported

175	DST_R_ADD_BONE_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

176	DST_R_ADD_ASCITES	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Ascites
Allowable Values 1 yes 2 not reported

177	DST_R_ADD_ASCITES_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

178	DST_R_ADD_NONMES_LN	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Non mesenteric lymph nodes (except supraclavicular)
Allowable Values 1 yes 2 not reported

179	DST_R_ADD_NONMES_LN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

180	DST_R_ADD_NONMES_LN_TXT	string (250)	Required:false
	Free test describing non-mesenteric lymph nodes (except supraclavicular) involved in additional distant recurrence

181	DST_R_ADD_SUPRA_LN	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Supraclavicular nodes
Allowable Values 1 yes 2 not reported

182	DST_R_ADD_SUPRA_LN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

183	DST_R_ADD_BRAIN	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Brain
Allowable Values 1 yes 2 not reported

184	DST_R_ADD_BRAIN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

185	DST_R_ADD_SKIN	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Skin, except incision Specify site (text):
Allowable Values 1 yes 2 not reported

186	DST_R_ADD_SKIN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

187	DST_R_ADD_SKIN_TXT	string (250)	Required:false
	Free text describing site of additional distant recurrence in skin

188	DST_R_ADD_ADRENAL	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Adrenal gland
Allowable Values 1 yes 2 not reported

189	DST_R_ADD_ADRENAL_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

190	DST_R_ADD_OTH	number (1,0)	Required:false
	Site(s) of involvement at time of additional distant recurrence Other Specify site (text):
Allowable Values 1 yes 2 not reported

191	DST_R_ADD_OTH_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

192	DST_R_ADD_OTH_TXT	string (250)	Required:false
	Free text describing other site of additional distant recurrence

193	NEW_CRC_PRIM	number (1,0)	Required:true
	Did the proband have a new primary colorectal cancer diagnosis after the original CRC diagnosis (after start date to final chart date)? NOTE: Additional cancer information may exist in the individual.CANCER table
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

194	NEW_CRC1_TUMOR_NO	number (2,0)	Required:true
	Tumor number should correspond with information from the CANCER file

195	NEW_CRC1_ICD	string (7)	Required:false
	ICD code of 1st new CRC PRIMARY If SYNCHRONOUS primaries, please record the LARGEST. (NEW_PRIMARY_1)

196	NEW_CRC1_DXDATE	string (8)	Required:false
	DIAGNOSIS DATE OF 1st New CRC PRIMARY
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

197	NEW_CRC1_SURG	number (1,0)	Required:false
	Surgical treatment performed for 1st New CRC PRIMARY?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

198	NEW_CRC1_SURG_TYPE	number (2,0)	Required:false
	Type of surgical treatment for new CRC primary (Can use SEER coding)
Allowable Values 2 Local tumor destruction, i.e. laser, electrocautery 3 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 4 Right Hemi colectomy 5 Left Hemi colectomy 6 Hemi colectomy Side not specified: not total 7 Low Anterior resection 8 Total Colectomy 9 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other (Specify): 88 Not Asked 99 Unknown

199	NEW_CRC1_SURG_TYPE_TXT	string (250)	Required:false
	Free text describing other type of surgery for 1st new CRC primary

200	NEW_CRC1_SURG_DATE	string (8)	Required:false
	Date of 1st resection for 1st new CRC primary
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

201	NEW_CRC1_SURG_LOCAL	number (1,0)	Required:false
	Operative findings , local (residual tumor) for 1st new CRC primary (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not Asked 9 Unknown

202	NEW_CRC1_SURG_OTHORG	number (1,0)	Required:false
	Were other organs (partial or total) removed at definitive surgery for 1st new CRC primary ?
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

203	NEW_CRC1_SURG_OTHORG_SM_INTEST	number (1,0)	Required:false
	If small intestine (partial or total) were removed, please specify:
Allowable Values 1 yes 2 not reported

204	NEW_CRC1_SURG_OTHORG_LIVER	number (1,0)	Required:false
	If liver (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

205	NEW_CRC1_SURG_OTHORG_APPENDIX	number (1,0)	Required:false
	If appendix (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

206	NEW_CRC1_SURG_OTHORG_OVARY_NOS	number (1,0)	Required:false
	If ovary (partial or total) were removed and no information on which side (left or right) , please specify:
Allowable Values 1 yes 2 not reported

207	NEW_CRC1_SURG_OTHORG_OVARY_R	number (1,0)	Required:false
	If right ovary (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

208	NEW_CRC1_SURG_OTHORG_OVARY_L	number (1,0)	Required:false
	If left ovary (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

209	NEW_CRC1_SURG_OTHORG_OVARY_B	number (1,0)	Required:false
	If both ovaries (partial or total) were removed, please specify:
Allowable Values 1 yes 2 not reported

210	NEW_CRC1_SURG_OTHORG_SPLEEN	number (1,0)	Required:false
	If spleen (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

211	NEW_CRC1_SURG_OTHORG_BLADDER	number (1,0)	Required:false
	If bladder (partial or total) was removed, please specify:
Allowable Values 1 yes 2 not reported

212	NEW_CRC1_SURG_OTHORG_OTH	number (1,0)	Required:false
	If other organs (partial or total) were removed, please specify:
Allowable Values 1 yes 2 not reported

213	NEW_CRC1_SURG_OTHORG_OTH_TXT	string (250)	Required:false
	Free text describing other organs (partial or total) removed COMMA SEPERATED IF MORE THAN ONE

214	NEW_CRC1_SURG_MARGIN	number (1,0)	Required:false
	Did the 1st new CRC primary reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

215	NEW_CRC1_MET	number (1,0)	Required:false
	Was distant metastatic disease found at surgery for 1st new CRC primary?
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

216	NEW_CRC1_MET_ASCITES	number (1,0)	Required:false
	Site of Metastatic Disease: Ascites
Allowable Values 1 yes 2 not reported

217	NEW_CRC1_MET_MESEN_LN	number (1,0)	Required:false
	Site of Metastatic Disease: Mesenteric lymph nodes, other than in mesentery of planned resection
Allowable Values 1 yes 2 not reported

218	NEW_CRC1_MET_LIVER	number (1,0)	Required:false
	Site of Metastatic Disease: Liver
Allowable Values 1 yes 2 not reported

219	NEW_CRC1_MET_LUNG	number (1,0)	Required:false
	Site of Metastatic Disease: Lung
Allowable Values 1 yes 2 not reported

220	NEW_CRC1_MET_OMENTUM	number (1,0)	Required:false
	Site of Metastatic Disease: Omentum
Allowable Values 1 yes 2 not reported

221	NEW_CRC1_MET_ABD_WALL	number (1,0)	Required:false
	Site of Metastatic Disease: Abdominal wall
Allowable Values 1 yes 2 not reported

222	NEW_CRC1_MET_OVARY	number (1,0)	Required:false
	Site of Metastatic Disease: Ovary(s)
Allowable Values 1 yes 2 not reported

223	NEW_CRC1_MET_BONE	number (1,0)	Required:false
	Site of Metastatic Disease: Bone
Allowable Values 1 yes 2 not reported

224	NEW_CRC1_MET_PERITO	number (1,0)	Required:false
	Site of Metastatic Disease: Peritoneum
Allowable Values 1 yes 2 not reported

225	NEW_CRC1_MET_MESEN	number (1,0)	Required:false
	Site of Metastatic Disease: Mesentery
Allowable Values 1 yes 2 not reported

226	NEW_CRC1_MET_OTH	number (1,0)	Required:false
	Site of Metastatic Disease: Other
Allowable Values 1 yes 2 not reported

227	NEW_CRC1_MET_OTH_TXT	string (250)	Required:false
	Free text describing other site of Metastatic Disease COMMA SEPERATED IF MORE THAN ONE

228	NEW_CRC1_MET_RESECT	number (1,0)	Required:false
	Was this metastasis resected immediately (within 3 months) after baseline surgery) (if applicable)
Allowable Values 1 All metastases entirely resected 2 At least one metastasis not entirely resected 3 Not resected (No surgery) 8 Not Asked 9 Unknown

229	NEW_CRC1_MET_RESECT_DATE	string (8)	Required:false
	Date metastasis was resected (only if metastasis was completely or incompletely resected):
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

230	NEW_CRC1_T	number (1,0)	Required:false
	Clinicopathologic summary stage of disease. Tumor Stage of 1st new CRC primary (0-4)
Allowable Values 0 Carcinoma in situ/TIS 1 Tumor invades submucosa 2 Tumor invades muscularis propria 3 Tumor invades through muscularis propria into submucosa or into non peritonealized pericolic or perirectal tissues 4 Tumor directly invades other organs/structures/perforates visceral peritonium 8 Not Asked 9 Unknown

231	NEW_CRC1_N	number (1,0)	Required:false
	Nodal stage of 1st new CRC primary (0-3)
Allowable Values 0 No regional lymph node metastasis 1 Metastasis in 1 to 3 regional lymph nodes 2 Metastasis in 4 or more regional lymph nodes 8 Not Asked 9 Unknown

232	NEW_CRC1_M	number (1,0)	Required:false
	Metastasis stage of 1st new CRC primary (0-1)
Allowable Values 0 No distant metastasis 1 Distant metastasis is present 8 Not Asked 9 Unknown

233	NEW_CRC1_T_SRC	number (1,0)	Required:false
	Source of information for tumor stage:
Allowable Values 1 Pathology Report 2 Clinic Note/Discharge Summary 3 Other Specify (text): 8 Not Asked 9 Unknown

234	NEW_CRC1_T_SRC_TXT	string (250)	Required:false
	Source of information for tumor stage: OTHER

235	NEW_CRC1_N_SRC	number (1,0)	Required:false
	Source of information for nodal stage:
Allowable Values 1 Pathology Report 2 Clinic Note/Discharge Summary 3 Other Specify (text): 8 Not Asked 9 Unknown

236	NEW_CRC1_N_SRC_TXT	string (250)	Required:false
	Source of information for nodal stage: OTHER

237	NEW_CRC1_M_SRC	number (1,0)	Required:false
	Source of information for metastasis stage):
Allowable Values 1 Pathology Report 2 Clinic Note/Discharge Summary 3 Operative Note 4 Radiology report (US, CT, MRI etc.) 5 Other Specify (text): 8 Not Asked 9 Unknown

238	NEW_CRC1_M_SRC_TXT	string (250)	Required:false
	Source of information for metastasis stage: OTHER

239	NEW_CRC1_CHEMO	number (1,0)	Required:false
	Was chemotherapy given for treatment of the new primary colorectal cancer(s)?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

240	NEW_CRC1_CHEMO_METHOD	number (1,0)	Required:false
	What method of chemotherapy was applied for treatment of the new primary colorectal cancer(s)? Note: Multiple methods and agents are possible. If so they should be recorded in order given ie Neo Adjuvant first > Adjuvant > Palliative last
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

241	NEW_CRC1_CHEMO1_DATE	string (8)	Required:false
	Date of 1st chemotherapy treatment of the CRC primary(s) in the eligibility period
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

242	NEW_CRC1_CHEMO1_AGT	number (1,0)	Required:false
	Pseudo gateway question to capture overall "missing/unknown agent"
Allowable Values 1 specified 8 Not Asked 9 Unknown

243	NEW_CRC1_CHEMO1_AGT_5FU	number (1,0)	Required:false
	5 FU / FLUOROURACIL/ ADRUCIL CHEMOTHERAPEUTIC AGENT first course only. Does not include medications given to control or suppress side effect. Also the list is abbreviated and another variable "other" added to list additional drugs
Allowable Values 1 yes 2 not reported

244	NEW_CRC1_CHEMO1_AGT_FA	number (1,0)	Required:false
	FA (FOLINIC ACID) / LEUCOVORIN / WELLCOVORIN
Allowable Values 1 yes 2 not reported

245	NEW_CRC1_CHEMO1_AGT_CPT11	number (1,0)	Required:false
	CPT11/ IRINOTECAN / CAMPTOSAR
Allowable Values 1 yes 2 not reported

246	NEW_CRC1_CHEMO1_AGT_OXAL	number (1,0)	Required:false
	OXALIPLATIN / ELOXATIN
Allowable Values 1 yes 2 not reported

247	NEW_CRC1_CHEMO1_AGT_LEVA	number (1,0)	Required:false
	LEVAMISOLE
Allowable Values 1 yes 2 not reported

248	NEW_CRC1_CHEMO1_AGT_XELO	number (1,0)	Required:false
	XELODA / CAPECITABINE
Allowable Values 1 yes 2 not reported

249	NEW_CRC1_CHEMO1_AGT_AVAS	number (1,0)	Required:false
	AVASTIN / BEVACIZUMAB
Allowable Values 1 yes 2 not reported

250	NEW_CRC1_CHEMO1_AGT_ERBI	number (1,0)	Required:false
	ERBITUX/ CETUXIMAB
Allowable Values 1 yes 2 not reported

251	NEW_CRC1_CHEMO1_AGT_GEMZ	number (1,0)	Required:false
	GEMZAR
Allowable Values 1 yes 2 not reported

252	NEW_CRC1_CHEMO1_AGT_OTH	number (1,0)	Required:false
	OTHER AGENT CHEMOTHERAPEUTIC AGENT
Allowable Values 1 yes 2 not reported

253	NEW_CRC1_CHEMO1_AGT_OTH_TXT	string (250)	Required:false
	Free text describing OTHER CHEMOTHERAPEUTIC AGENT, COMMA SEPERATED IF MORE THAN ONE

254	NEW_CRC1_RAD	number (1,0)	Required:false
	Was radiation given for treatment of the new primary colorectal cancer(s)?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

255	NEW_CRC1_RAD_METHOD	number (1,0)	Required:false
	What method of radiotherapy was applied for treatment of the new primary colorectal cancer(s)?
Allowable Values 1 Adjuvant 2 Palliative 3 Pseudo Adjuvant 4 Neo Adjuvant (pre operative) 8 Not Asked 9 Unknown

256	NEW_CRC1_RAD1_DATE	string (8)	Required:false
	Date of 1st radiotherapy treatment of the CRC primary(s) in the eligibility period
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

257	NEW_CRC1_TREAT_OTH	number (1,0)	Required:false
	Were other treatment methods applied for new primary colorectal cancer(s)?
Allowable Values 1 Yes (Specify) 2 No 8 Not Asked 9 Unknown

258	NEW_CRC1_TREAT_OTH_TXT	string (250)	Required:false
	free text describing 1st other treatment methods applied for new CRC primary (NEW_CRC1_TREAT_OTH=1,2), Comma separated list of other agents(s

259	NEW_CRC1_SYNC	number (1,0)	Required:false
	Were synchronous new CRC primaries diagnosed?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

260	NEW_CRC1_SYNC_NUM	number (2,0)	Required:false
	#_____ of SYNCHRONOUS PRIMARY(S)
Allowable Values 1 to 8 or 88, 99 Range 88 Not asked 99 unknown

261	NEW_CRC1_SYNC2_TUMOR_NO	number (2,0)	Required:true
	Tumor number should correspond with information from the CANCER file

262	NEW_CRC1_SYNC2_ICD	string (7)	Required:false
	ICD code of 2nd SYNCHRONOUS new CRC PRIMARY DIAGNOSIS TYPE. (Please record the 2nd largest. (NEW_PRIMARY_2)

263	NEW_CRC1_SYNC2_DXDATE	string (8)	Required:false
	DIAGNOSIS DATE OF 2nd SYNCHRONOUS new CRC PRIMARY
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

264	NEW_CRC1_SYNC2_SURG_TYPE	number (2,0)	Required:false
	Surgical treatment for 2nd synchronous new CRC (Can use SEER coding to derive)
Allowable Values 1 No Surgery 2 Local tumor destruction, i.e. laser, electrocautery 3 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 4 Right Hemi colectomy 5 Left Hemi colectomy 6 Hemi colectomy Side not specified: not total 7 Low Anterior resection 8 Total Colectomy 9 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other (Specify): 88 Not Asked 99 Unknown

265	NEW_CRC1_SYNC2_SURG_TYPE_TXT	string (250)	Required:false
	free text describing other surgery for 2nd synchronous new CRC

266	NEW_CRC1_SYNC2_SURG_LOCAL	number (1,0)	Required:false
	Operative findings , local (residual tumor) (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not Asked 9 Unknown

267	NEW_CRC1_SYNC2_SURG_MARGIN	number (1,0)	Required:false
	Did the tumor reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

268	NEW_CRC1_SYNC3_TUMOR_NO	number (2,0)	Required:true
	Tumor number should correspond with information from the CANCER file

269	NEW_CRC1_SYNC3_ICD	string (7)	Required:false
	ICD code of 3rd SYNCHRONOUS new CRC PRIMARY DIAGNOSIS TYPE. (Please record the 3rd largest. (NEW_PRIMARY_3)

270	NEW_CRC1_SYNC3_DXDATE	string (8)	Required:false
	DIAGNOSIS DATE OF 3rd SYNCHRONOUS new CRC PRIMARY IN THE ELIGIBILITY PERIOD
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

271	NEW_CRC1_SYNC3_SURG_TYPE	number (2,0)	Required:false
	Surgical treatment for 3rd SYNCHRONOUS new CRC primary (Can use SEER coding to derive)
Allowable Values 1 No Surgery 2 Local tumor destruction, i.e. laser, electrocautery 3 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 4 Right Hemi colectomy 5 Left Hemi colectomy 6 Hemi colectomy Side not specified: not total 7 Low Anterior resection 8 Total Colectomy 9 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other (Specify): 88 Not Asked 99 Unknown

272	NEW_CRC1_SYNC3_SURG_TYPE_TXT	string (250)	Required:false
	Free text describing other surgery for 3rd synchronous new CRC

273	NEW_CRC1_SYNC3_SURG_LOCAL	number (1,0)	Required:false
	Operative findings , local (residual tumor) or 3rd synchronous new CRC (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not Asked 9 Unknown

274	NEW_CRC1_SYNC3_SURG_MARGIN	number (1,0)	Required:false
	Did the or 3rd synchronous new CRC reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

275	NEW_CRC2_PRIM	number (1,0)	Required:false
	Was second "non Synchronous" CRC diagnosed within the follow-up period after the diagnosis of first new CRC? NOTE: Additional cancer information may exist in the individual.CANCER table
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

276	NEW_CRC2_TUMOR_NO	number (2,0)	Required:true
	Tumor number should correspond with information from the CANCER file

277	NEW_CRC2_ICD	string (7)	Required:false
	second "non synchronous" CRC diagnosed within the follow-up period (within 4 yrs of incidence CRC)

278	NEW_CRC2_DXDATE	string (8)	Required:false
	Diagnosis Date 2nd new "non-synchronous" CRC primary(s) in the follow-up period
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

279	NEW_CRC2_SURG_TYPE	number (2,0)	Required:false
	Surgical treatment for 2nd non-synchronous CRC (Can use SEER coding to derive)
Allowable Values 1 No Surgery 2 Local tumor destruction, i.e. laser, electrocautery 3 Local surgical excision with specimen i.e. trans anal excision, polypectomy, snare 4 Right Hemi colectomy 5 Left Hemi colectomy 6 Hemi colectomy Side not specified: not total 7 Low Anterior resection 8 Total Colectomy 9 Total Proctectomy 10 Total Proctocolectomy 11 Abdominoperineal resection 12 Segmental / Wedge / Partial Resection NOS 77 Other (Specify): 88 Not Asked 99 Unknown

280	NEW_CRC2_SURG_TYPE_TXT	string (250)	Required:false
	Free text describing other surgical treatment for 2nd non-synchronous CRC

281	NEW_CRC2_SURG_TYPE_LOCAL	number (1,0)	Required:false
	Operative findings , local (residual tumor) 2nd non-synchronous CRC (obtain information from the operative report and/or the discharge summary NOT pathology report)
Allowable Values 1 Tumor not entirely resected 2 Tumor entirely resected 8 Not Asked 9 Unknown

282	NEW_CRC2_SURG_TYPE_MARGIN	number (1,0)	Required:false
	Did the 2nd non-synchronous CRC reach surgical resection margins? (Source: Pathology report)
Allowable Values 1 Positive, proximal (Tumor is seen at proximal surgical resection margin) 2 Positive, distal (Tumor is seen at distal surgical resection margin) 3 Positive, radial (Tumor is seen at radial surgical resection margin) 4 Positive, more than one margins defined. 5 Positive, NOS (Tumor is seen at surgical resection margin, margin not defined) 6 Negative (all surgical resection margins are free of tumor) 8 Not Asked 9 Unknown

283	NEW_CRC2_SYNC	number (1,0)	Required:false
	Were 2nd synchronous new CRC primaries diagnosed?
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

284	NEW_CRC2_SYNC_NUM	number (2,0)	Required:false
	#_____ of 2nd SYNCHRONOUS PRIMARY(S)
Allowable Values 1 to 8 or 88, 99 Range 88 Not asked 99 unknown

285	NEW_NONCRC_PRIM	number (1,0)	Required:false
	Did the proband have a new non-CRC primary diagnosis after the original CRC diagnosis (after incident CRC date to date of final chart note) NOTE: Additional cancer information may exist in the individual.CANCER table
Allowable Values 1 Yes 2 No 8 Not Asked 9 Unknown

286	NEW_NONCRC1_ICD	string (7)	Required:false
	ICD code for 1st new non-CRC PRIMARY

287	NEW_NONCRC2_ICD	string (7)	Required:false
	ICD code for 2nd new non-CRC PRIMARY

288	NEW_NONCRC3_ICD	string (7)	Required:false
	ICD code for 3rd new non-CRC PRIMARY

289	LAST_STATUS	number (1,0)	Required:true
	final vital status with cause of death (COD)
Allowable Values 1 alive and cancer free 2 alive with cancer 3 alive cancer status unknown 4 deceased due to Cancer 5 deceased not due to cancer 6 deceased cancer status unknown 7 deceased cause unknown 8 Not Asked 9 Unknown

290	DEATH_DATE	string (8)	Required:false
	DATE OF DEATH
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

291	DEATH_CAUSE	string (25)	Required:false
	What was the patient??s cause of death? Cause of Death: (if known use ICD code)

292	LAST_CHART_DATE	string (8)	Required:false
	Date of Last (Most Recent) Physician Chart Note found by the Abstractor (Operative Notes, Discharge Summary, Clinic Notes, Chemotherapy and/or Radiotherapy Notes)
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

293	COMPLETE_DATE	string (8)	Required:false
	Date Form Completed (date review/abstraction completed)
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

294	LR_DST_RECUR	number (1,0)	Required:false
	Did the patient have at least one locoregional or distal recurrence after CRC diagnosis? (Ideally interval between diagnosis date and final chart review date should be at least 4 years)
Allowable Values 1 Yes and site/organ specified 2 Yes but site/organ not specified 3 No 8 Not asked 9 Unknown

295	LR_DST1_ANAST	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional or distal recurrence (please circle all that apply): Anastomosis:
Allowable Values 1 yes 2 Not reported

296	LR_DST1_ANAST_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

297	LR_DST1_MESEN	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Mesentery
Allowable Values 1 yes 2 Not reported

298	LR_DST1_MESEN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

299	LR_DST1_ABD_WALL	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Abdominal Wall (not incisional)
Allowable Values 1 yes 2 Not reported

300	LR_DST1_ABD_WALL_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

301	LR_DST1_INCS	number (1,0)	Required:false
	Site(s) of involvement at time of first locoregional recurrence (please circle all that apply): Incisional
Allowable Values 1 yes 2 Not reported

302	LR_DST1_INCS_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

303	LR_DST1_PELVIS	number (1,0)	Required:false
	Site(s) of involvement at time of first distal or locoregional recurrence (please circle all that apply): Pelvis
Allowable Values 1 yes 2 Not reported

304	LR_DST1_PELVIS_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

305	LR_DST1_LIVER	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Liver
Allowable Values 1 yes 2 Not reported

306	LR_DST1_LIVER_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

307	LR_DST1_LUNG	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Lung
Allowable Values 1 yes 2 Not reported

308	LR_DST1_LUNG_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

309	LR_DST1_BONE	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Bone
Allowable Values 1 yes 2 Not reported

310	LR_DST1_BONE_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

311	LR_DST1_ASCITES	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Ascites
Allowable Values 1 yes 2 Not reported

312	LR_DST1_ASCITES_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

313	LR_DST1_NONMES_LN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Non-mesenteric lymph nodes (except supraclavicular)
Allowable Values 1 yes 2 Not reported

314	LR_DST1_NONMES_LN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

315	LR_DST1_NONMES_LN_TXT	string (250)	Required:false
	Free text describing specific non-mesenteric lymph nodes (except supraclavicular)

316	LR_DST1_SUPRA_LN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Supraclavicular nodes
Allowable Values 1 yes 2 Not reported

317	LR_DST1_SUPRA_LN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

318	LR_DST1_BRAIN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Brain
Allowable Values 1 yes 2 Not reported

319	LR_DST1_BRAIN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

320	LR_DST1_SKIN	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence: Skin, except incision Specify site (text):
Allowable Values 1 yes 2 Not reported

321	LR_DST1_SKIN_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

322	LR_DST1_SKIN_TXT	string (250)	Required:false
	Free text describing first distant or locoregional recurrence in skin, except incision

323	LR_DST1_ADRENAL	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence: Adrenal gland
Allowable Values 1 yes 2 Not reported

324	LR_DST1_ADRENAL_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD

325	LR_DST1_OTH	number (1,0)	Required:false
	Site(s) of involvement at time of first distant or locoregional recurrence Other Specify site (text):
Allowable Values 1 Yes 2 Not reported

326	LR_DST1_OTH_TXT	string (250)	Required:false
	Free text describing other site of first distant or locoregional recurrence

327	LR_DST1_OTH_DATE	string (8)	Required:false
	First Diagnosed Month First Diagnosed Day (optional) First Diagnosed Year
Date Value Check The date must follow to the following format: Format YYYYMMDD. Must consist of valid date. Components of date should be right justified and zero filled. MM = 01 - 12, 88, 99 DD = 01 - 31, 88, 99 YYYY = Minimum year - system date year, 8888, 9999 Use 88, 8888 for not currently known, in progress to obtain information. Use 99, 9999 for not known. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If MM = 99 then DD must = 99. If century is known, but year is unknown then give an estimate of year or code YYYY = 9999. If YYYY = 9999 then MM and DD must = 99. The following special parameters are used: 1900 Minimum year Error Description must be a valid date of format YYYYMMDD