Module: colorectal-path

Module Contents

colorectal-malig
- 1.CENTER_NO
- 2.PERSON_ID
- 3.TUMOR_NO
- 4.DT_EVAL
- 5.BLOCK_SPEC_CID
- 6.PROCEDURE_TYPE
- 7.MAT_REV_SLIDE
- 8.MAT_REV_PATH_RPT
- 9.MAT_REV_HOSP_REC
- 10.MAT_REV_CA_REGISTRY
- 11.MAT_REV_UNK
- 12.SPEC_EXAM
- 13.PRIM_SITE_CAT
- 14.PRIM_HIST_CAT
- 15.PRIM_HIST_CAT_OTH_TXT
- 16.TUMOR_SIZE
- 17.GRADE
- 18.MACROSC_TUM_PERF
- 19.MARGIN
- 20.LC_PERI
- 21.LC_CROHN
- 22.LC_INFIL
- 23.LOC_EXCIS
- 24.MARG_INV_DISTAL
- 25.MARG_INV_PROXIMAL
- 26.MARG_INV_RADIAL
- 27.MARG_INV_UNKNOWN
- 28.VEN_INV
- 29.LYMPHATIC_INV
- 30.PERINEURAL_INV
- 31.NEOADJ_TRT
- 32.NEOADJ_TRT_TYPE
- 33.CLINICAL_T
- 34.CLINICAL_N
- 35.CLINICAL_M
- 36.cTNM_STAGE
- 37.T_STAGE
- 38.LN
- 39.LN_POS
- 40.LN_EX
- 41.DIST_SPREAD
- 42.MET_SITE
- 43.MET_SITE_BONE
- 44.MET_SITE_BRAIN
- 45.MET_SITE_LIVER
- 46.MET_SITE_LUNG
- 47.MET_SITE_NODES
- 48.MET_SITE_OVARY
- 49.MET_SITE_PERITONEAL
- 50.MET_SITE_SMLBWL
- 51.MET_SITE_OTHER
- 52.MET_SITE_UNKNOWN
- 53.MET_SITE_OTH_TXT
- 54.MET_SITE_SRC
- 55.pTNM_STAGE
- 56.SYNCHRON
- 57.ADJ_ADEN
- 58.ADJ_ADEN_TYPE
- 59.ADJ_SIZE
- 60.ADJ_GRADE

CENTER_NO

number (2,0)

Required:true

Center identification number.

Allowable Values
11	Sinai Health Systems (formerly Cancer Care Ontario)
12	University of Southern California Consortium (USCC)
13	University of Melbourne
14	University of Hawaii Cancer Center
15	Mayo Clinic
16	Fred Hutch, Seattle
17	University of California at San Francisco (UCSF) (formerly CPIC, originally Northern California (NCCC))

2	PERSON_ID	string (12)	Required:true
	Number that uniquely identifies an individual.

TUMOR_NO

number (2,0)

Required:true

Computer generated sequential number, starting with 1, assigned to each tumor for a given individual when entered into the local system. No adjustment is made when a tumor is deleted from the system. Tumor numbers are never reused. PERSON_NO, TUMOR_NO uniquely identifies each tumor in the CIS. Tumor number should correspond with information from the CANCER file from Volume I.

DT_EVAL

string (8)

Required:true

Date specimen evaluated by treating institution (not by CCFR site)

5	BLOCK_SPEC_CID	string (9)	Required:false
	Unique local identifier used at a center to uniquely identify a block tissue specimen.

PROCEDURE_TYPE

number (1,0)

Required:true

Surgical procedure from which the specimen was obtained.

Allowable Values
1	Biopsy
2	Resection
3	Polypectomy
9	Unknown

MAT_REV_SLIDE

number (1,0)

Required:true

Materials reviewed included slides.

Allowable Values
1	Yes
2	No
9	Unknown

MAT_REV_PATH_RPT

number (1,0)

Required:true

Materials reviewed included pathology report.

Allowable Values
1	Yes
2	No
9	Unknown

MAT_REV_HOSP_REC

number (1,0)

Required:true

Materials reviewed included hospital records.

Allowable Values
1	Yes
2	No
9	Unknown

MAT_REV_CA_REGISTRY

number (1,0)

Required:true

Materials reviewed included cancer registry data.

Allowable Values
1	Yes
2	No
9	Unknown

MAT_REV_UNK

number (1,0)

Required:true

Materials reviewed unknown.

Allowable Values
1	Yes
2	No
9	Unknown

SPEC_EXAM

number (1,0)

Required:true

Was specimen examined from primary site or metastatic site?.

Allowable Values
1	Primary site
2	Metastatic site
3	Both
9	Unknown

PRIM_SITE_CAT

number (1,0)

Required:true

Primary site of colorectal cancer; Should include hepatic and splenic flexures with transverse colon.

Allowable Values
1	Caecum (illeocaecal)
2	Ascending (hepatic flexure)
3	Transverse (splenic flexure)
4	Descending
5	Sigmoid
6	Rectum (rectosigmoid)
7	Appendix
9	Unknown/NOS/not reported

PRIM_HIST_CAT

number (1,0)

Required:true

Categorization of histologic type of colorectal primary site; In mucinous carcinomas at least 50% of the tumor comprises areas in which mucin secretion is abundant (more mucus than epithelium). Most poorly differentiated solid types include areas of adenocarcinoma and should not be called undifferentiated. In signet ring cell cancers, 50% of the tumor is composed of signet ring cells.

Allowable Values
1	Adenocarcinoma
2	Mucinous
3	Signet ring
4	Undifferentiated (including medullary)
5	Other
9	Unknown

15	PRIM_HIST_CAT_OTH_TXT	string(250)	Required:false
	Specify primary histologic category text. (Answer if PRIM_HIST_CAT=5)

TUMOR_SIZE

number (3,0)

Required:true

Size (mm) of tumor.

Allowable Values
1 to 200	Range
0	No mass
999	Unknown

GRADE

number (1,0)

Required:true

Grade (worst); The worst area should be graded. Minor fragmentation of glands at the growing tumor margin should be ignored. Well-differentiated cancers have well-formed glands relatively uniform nuclear characteristics. There is a resemblance to adenomatous epithelium. Moderately differentiated cancers have irregular glands but a glandular architecture is still obvious. In poorly differentiated cancers glandular architecture is discerned with difficulty. These are well circumscribed with solid sheets and/or trabeculae and/or cribiforing and/or signet ring areas.

Allowable Values
1	Low grade/well differentiated/G1
2	Low grade/moderately differentiated/G2
3	High grade/poorly differentiated/G3
4	Undifferentiated/G4
9	Unknown

MACROSC_TUM_PERF

number (1,0)

Required:true

Macroscopic tumor perforation. (Do not confuse with microscopic penetration of serosal surface).

Allowable Values
1	Present
2	Absent
9	Unknown

MARGIN

number (1,0)

Required:false

Tumor margin; Cancers considered, as intermediate between expanding and infiltrating should be grouped with the expanding subset. An infiltrating growth pattern may be suspected by naked eye examination of the slide because the pink muscle and blue tumor are merged and difficult to distinguish. Microscopically, infiltrating cancers dissect between muscle bundles, often with a ”raining down” pattern. There is often diffuse infiltration of fat, perineurial invasion and vascular invasion.

Allowable Values
1	Expanding/pushing
2	Infiltrating/irregular
9	Unknown

LC_PERI

number (1,0)

Required:false

Peritumoral lymphocytes; The presence of peritumoral lymphocytes indicates a distinct inflammatory cuff or cap at the deepest point of penetration of the tumor. The inflammatory cells include neutrophils, eosinophils, macrophages and plasma cells as well as lymphocytes.

Allowable Values
1	Yes
2	No
9	Unknown

LC_CROHN

number (1,0)

Required:false

Crohn”s-like Lymphocytes; The Crohn”s-like reaction refers to lymphocytes arranged in aggregates or nodules, mainly away from the cancer and in the perirectal or mesenteric fat. It is suggested that at least three lymphoid aggregates should be present in a section.

Allowable Values
1	Yes
2	No
9	Unknown

LC_INFIL

number (1,0)

Required:false

Tumor infiltrating lymphocytes. In marked infiltration, the malignant epithelium is peppered with lymphocytes. The ratio of nuclei (lymphocyte: epithelial) should be at least 1:10 (or at least 12 intraepithelial lymphocytes within a high power (40) field) in the most obviously affected areas (about 3% of cases). Mild infiltration means that the lymphocyte: epithelial ratio should be at least 1:25 (or at least 5 unequivocal intraepithelial lymphocytes within one high power (40) field) in the most obviously affected areas (about 17% of cases). None means a lower frequency or none detected after searching for one minute (about 80% if cases).

Allowable Values
1	Yes, marked
2	Yes, mild
3	No
9	Unknown

LOC_EXCIS

number (1,0)

Required:true

Local excision

Allowable Values
1	Complete (all margins negative for malignancy)
2	Incomplete (one or more margins positive for malignancy)
9	Unknown

MARG_INV_DISTAL

number (1,0)

Required:false

Did tumor reach surgical resection distal margin? (Answer if LOC_EXCIS=2)

Allowable Values
1	Yes
2	No
9	Unknown

MARG_INV_PROXIMAL

number (1,0)

Required:false

Did tumor reach surgical resection proximal margin? (Answer if LOC_EXCIS=2)

Allowable Values
1	Yes
2	No
9	Unknown

MARG_INV_RADIAL

number (1,0)

Required:false

Did tumor reach surgical resection radial margin? (Answer if LOC_EXCIS=2)

Allowable Values
1	Yes
2	No
9	Unknown

MARG_INV_UNKNOWN

number (1,0)

Required:false

Which surgical resection margin(s) involved are unknown? (Answer if LOC_EXCIS=2)

Allowable Values
1	Yes
2	No
9	Unknown

VEN_INV

number (1,0)

Required:false

Venous invasion (note: formerly called vascular invasion VAS_INV).

Allowable Values
1	Yes
2	No
9	Unknown

LYMPHATIC_INV

number (1,0)

Required:false

Lymphatic invasion.

Allowable Values
1	Yes
2	No
9	Unknown

PERINEURAL_INV

number (1,0)

Required:false

Perineural invasion.

Allowable Values
1	Yes
2	No
9	Unknown

NEOADJ_TRT

number (1,0)

Required:true

Neoadjuvant treatment.

Allowable Values
1	Yes
2	No
9	Unknown

NEOADJ_TRT_TYPE

number (1,0)

Required:false

Neoadjuvant treatment type. (Answer if NEOADJ_TRT=1)

Allowable Values
1	Chemotherapy
2	Radiation
3	Both
9	Unknown

CLINICAL_T

number (1,0)

Required:false

T stage of colorectal cancer (T of TNM). From treatment data. (Answer if NEOADJ_TRT=1)

Allowable Values
0	Tis
1	T1
2	T2
3	T3
4	T4
9	Unknown

CLINICAL_N

number (1,0)

Required:false

Positive nodes? From treatment data. (Answer if NEOADJ_TRT=1)

Allowable Values
1	Yes
2	No
9	Unknown

CLINICAL_M

number (1,0)

Required:false

Metastasis? From treatment data. (Answer if NEOADJ_TRT=1)

Allowable Values
1	Yes
2	No
9	Unknown (no definitive statement of distant spread).

cTNM_STAGE

number (1,0)

Required:false

TNM Stage – Provide only if reported. Do not derive. From treatment data. (Answer if NEOADJ_TRT=1)

Allowable Values
0	In-situ
1	I
2	II
3	III
4	IV
9	Unknown (if distant spread is unknown)

T_STAGE

number (1,0)

Required:true

T stage of colorectal cancer (T of TNM). Note: Formerly called T_STAGE_M.

Allowable Values
0	Tis
1	T1
2	T2
3	T3
4	T4
9	Unknown

number (1,0)

Required:true

Positive nodes?

Allowable Values
1	Yes
2	No
9	Unknown

LN_POS

number (2,0)

Required:true

Number of positive nodes. Note: codes adopted from SEER & NAACCR standards.

Allowable Values
0 to 99	Range
0	All nodes examined negative
1-95	Number positive
96	96 or more positive nodes
97	Positive nodes, # of positive nodes not specified
98	No nodes examined
99	Unknown if nodes are positive or negative; not applicable

LN_EX

number (2,0)

Required:true

Total number of examined nodes. Note: codes adopted from SEER & NAACCR standards.

Allowable Values
0 to 90, 95, 96, 99	Range
0	No nodes examined
1-89	# of nodes examined
90	90 or more nodes examined
95	No nodes removed
96	Nodes examined: # unknown/not stated
99	Unknown if nodes examined; not applicable

DIST_SPREAD

number (1,0)

Required:true

Distant spread – colorectal cancer (M in TNM)

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE

number (1,0)

Required:false

Metastatic site. (Answer if DIST_SPREAD=1) Note: Only used for records received before January 20 2020.

Allowable Values
1	Liver
2	Other
8	NA (not applicable)
9	Unknown

MET_SITE_BONE

number (1,0)

Required:false

Metastatic site: Bone? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_BRAIN

number (1,0)

Required:false

Metastatic site: Brain/other CNS organ? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_LIVER

number (1,0)

Required:false

Metastatic site: Liver? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_LUNG

number (1,0)

Required:false

Metastatic site: Lung/other thoracic organ? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_NODES

number (1,0)

Required:false

Metastatic site: Distant lymph nodes? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_OVARY

number (1,0)

Required:false

Metastatic site: Ovary/other gynecologic organ? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_PERITONEAL

number (1,0)

Required:false

Metastatic site: Peritoneal cavity (includes ascites)? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_SMLBWL

number (1,0)

Required:false

Metastatic site: Small intestine? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_OTHER

number (1,0)

Required:false

Metastatic site: Other? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

MET_SITE_UNKNOWN

number (1,0)

Required:false

Metastatic site: Unknown? (Answer if DIST_SPREAD=1).

Allowable Values
1	Yes
2	No
9	Unknown

53	MET_SITE_OTH_TXT	string(80)	Required:false
	Specify other metastatic site. (Answer if MET_SITE_OTHER =1).

MET_SITE_SRC

number (1,0)

Required:false

Source of metastatic site report.

Allowable Values
1	Pathology Report
2	Clinical note
3	Operative note
4	Radiology report
5	Other
9	Unknown

pTNM_STAGE

number (1,0)

Required:true

TNM Stage – Provide only if reported. Do not derive. Note: Formerly called TNM

Allowable Values
0	in-situ lesions
1	I
2	II
3	III
4	IV
9	Unknown (if DIST_SPREAD scored 9 or unknown, TNM should be scored unknown).

SYNCHRON

number (1,0)

Required:true

Synchronous colorectal cancer.

Allowable Values
1	Yes
2	No
9	Unknown

ADJ_ADEN

number (1,0)

Required:false

Contiguous (adjacent) adenoma

Allowable Values
1	Yes
2	No
9	Unknown

ADJ_ADEN_TYPE

number (1,0)

Required:false

Type of contiguous (adjacent) adenoma (Answer if ADJ_ADEN=1)

Allowable Values
1	Tubular adenoma (TA)
2	Tubulovillous (TV)
3	Villous adenoma (VA)
4	Traditional serrated adenoma (TSA)
5	Hyperplastic polyp (HP)
6	Other (include mixed)
7	Adenomatous, type unspecified
8	Not Applicable) (If ADJ_ADEN equals 9)
9	Unknown
10	Sessile serrated polyp / lesion / adenoma (SSP/L/A)

ADJ_SIZE

number (3,0)

Required:false

Size (mm) of contiguous (adjacent) adenoma (Answer if ADJ_ADEN=1)

Allowable Values
0 to 990 or 998, 999	Range
0	No mass (ie. Flat adenoma)
1	Microscopic focus/foci
2 to 990	Size reported (in mm)
998	Not applicable (if ADJ_ADEN equals 2)
999	Unknown (if ADJ_ADEN equals 9

ADJ_GRADE

number (1,0)

Required:false

Grade of contiguous (adjacent) adenoma (Answer if ADJ_ADEN=1)

Allowable Values
1	Mild
2	Moderate
3	Severe/high/in-situ
4	No evidence of dysplasia
8	Not applicable (if ADJ_ADEN equals 2 or ADJ_ADEN_TYPE equals 5)
9	Unknown (If ADJ_ADEN equals 9)