TABLE 1. FAMILY RECRUITMENTa
 
  Male Female Total
       
Population-based Families*     13190
Case probandsb 4321 4419 8740
Affected relativesb 334 370 704
Unaffected relativesc 7768 10517 18285
Control probandsc 2071 2205 4276
Relatives of controls (Australia only) 310 467 777
Total population-based individuals 14804 17978 32782
       
Clinic-based Families**     1859
Affected probandsb 697 644 1341
Unaffected probandsc 139 304 443
Affected relativesb 441 461 902
Unaffected relativesc 3083 3941 7019
Total clinic-based individuals 4360 5350 9711
       
Total Individuals 19164 23328 42493
Total Families     15049
* Includes population-based case proband families from all sites and population-based control proband families from Australia site.
** Includes all clinic-based proband families (counts family ID of affected and unaffected clinic-based probands).
a. Baseline epi data (excluding proxy completion) for females and males
b. Affected with colorectal cancer at baseline interview or biospecimen collection
c. No history of colorectal cancer at baseline interview or biospecimen collection
Note: Blood and non-blood relatives/individuals excluding the probands.

 

TABLE 2. FAMILY DATAa
    Male Female Total
A.Population Based Case Colon Cancer Families      
Probandsb Baseline epi dataa 4321 4419 8740
  1st Follow-up epi data 2635 2966 5601
  2nd Follow-up epi data 1784 2059 3843
  3rd Follow-up epi data 849 1020 1869
  FFQ datae 2094 2406 4500
  Blood/buccal samples 3773 3855 7628
  Polyp material 15 8 23
  Tumor material 3506 3397 6903
  (CRC tumor material)i 3461 3335 6796
  (Other tumor material)j 106 147 253
  Clinical Dx and Treatment info 1817 1801 3618
Relativesc Baseline epi dataa 7740 10326 18066
  1st Follow-up epi data 5962 8222 14184
  2nd Follow-up epi data 4334 6104 10438
  3rd Follow-up epi data 2302 3237 5539
  FFQ datae 3279 4616 7895
  Blood/buccal samples 4730 6667 11397
  Polyp material 8 12 20
  Tumor material 300 367 667
  (CRC tumor material)i 236 244 480
  (Other tumor material)j 75 144 219
  Clinical Dx and Treatment info 49 50 99
Spouse Controlsf Baseline epi dataa 361 561 923
  1st Follow-up epi data 292 483 775
  2nd Follow-up epi data 221 384 605
  3rd Follow-up epi data 148 252 400
  FFQ datae 210 318 528
  Blood/buccal samples 325 510 835
  Polyp material 0 0 0
  Tumor material 4 10 14
  (CRC tumor material)i 1 3 4
  (Other tumor material)j 3 7 10
  Clinical Dx and Treatment info 0 0 0
         
B.Population Based Control Colon Cancer Families      
Probandsd Baseline epi dataa 2071 2205 4276
  1st Follow-up epi data 669 594 1263
  2nd Follow-up epi data 339 280 619
  3rd Follow-up epi data 0 0 0
  FFQ datae 1151 1025 2176
  Blood/buccal samples 1364 1424 2788
  Polyp material 0 0 0
  Tumor material 0 0 0
  (CRC tumor material)i 0 0 0
  (Other tumor material)j 0 0 0
  Clinical Dx and Treatment info 0 0 0
Relativesg Baseline epi dataa 310 467 777
  1st Follow-up epi data 0 0 0
  2nd Follow-up epi data 0 0 0
  3rd Follow-up epi data 0 0 0
  FFQ datae 259 382 641
  Blood/buccal samples 5 5 10
  Polyp material 0 0 0
  Tumor material 0 0 0
  (CRC tumor material)i 0 0 0
  (Other tumor material)j 0 0 0
  Clinical Dx and Treatment info 0 0 0
         
C.Clinic Based Colon Cancer Control Families*      
Affected Probandsb Baseline epi dataa 697 644 1341
  1st Follow-up epi data 492 486 978
  2nd Follow-up epi data 316 322 638
  3rd Follow-up epi data 124 140 264
  FFQ datae 235 252 487
  Blood/buccal samples 626 596 1222
  Polyp material 20 22 42
  Tumor material 568 528 1096
  (CRC tumor material)i 557 511 1068
  (Other tumor material)j 81 95 176
  Clinical Dx and Treatment info 321 257 578
Unaffected Probandsd Baseline epi dataa 139 304 443
  1st Follow-up epi data 125 276 401
  2nd Follow-up epi data 81 172 253
  3rd Follow-up epi data 33 70 117
  FFQ datae 73 183 256
  Blood/buccal samples 127 283 410
  Polyp material 18 34 52
  Tumor material 31 86 117
  (CRC tumor material)i 1 9 10
  (Other tumor material)j 30 82 112
  Clinical Dx and Treatment info 2 1 3
Relativesh Baseline epi dataa 3524 4402 7927
  1st Follow-up epi data 2939 3733 6673
  2nd Follow-up epi data 1963 2595 4558
  3rd Follow-up epi data 840 1208 2048
  FFQ datae 1922 2564 4486
  Blood/buccal samples 3039 3910 6950
  Polyp material 123 131 254
  Tumor material 472 585 1057
  (CRC tumor material)i 321 355 676
  (Other tumor material)j 170 276 446
  Clinical Dx and Treatment info 14 7 21

a. Baseline epi data (excluding proxy completion) for females and males

b. Affected with colorectal cancer at baseline interview or biospecimen collection

c. Affected and unaffected, blood and non-blood, relatives of population based case probands, at baseline interview.

d. No history of colon cancer at baseline interview.

e. Food Frequency Questionnaire

f. Non blood relation and spouse of case proband recruited to serve as a control.

g. Affected and unaffected, blood and non-blood, relatives of population based control probands, at baseline interview.

h. Affected and unaffected, blood and non-blood, relatives of clinic based probands, at baseline interview or biospecimen collection.

i. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

j. Individuals diagnosed with non-colorectal cancer and at least one tumor specimen obtained. 

* Includes all clinic-based probands and their blood or non-blood relatives