Summary Data - January 2022

Population based families

Clinic based families

 

 

 

 

TABLE 1. FAMILY RECRUITMENT
  Male Female Total
       
Population-based Familiesa     13188
Case probandsc 4318 4418 8736
Affected relativesc 339 381 720
Unaffected relativesd 7395 9951 17346
Spouse Controlse 363 560 923
Control probandsf 2071  2204  4275
Relatives of controls (Australia only)f 310 467 777
 Total population-based individuals 14796  17981  32777
       
Clinic-based Familiesb     1860
Affected probandsc 707 648 1355
Unaffected probandsd 130 300 430
Affected relativesc 444 465 909
Unaffected relativesd 3078 3935 7013
Total clinic-based individuals 4359 5348 9708
       
Total Individuals 19155 23329 42498
Total Families     15048
a. Includes CRC (colorectal cancer) -affected population-based case probands from all sites, ascertained through regional, state or provincial cancer registries; CRC-affected and unaffected familiy members; unrelated population-based control probands; and spouse controls.
b. Includes CRC-affected and CRC-unaffected proband families from Australia, Mayo Clinic, Cleveland Clinic, and Ontario ascertained through genetic and family cancer clinics.
c. CRC affected at baseline interview
d. CRC unaffected at baseline interview
e. Population-based case proband spouse recruited to serve as a control by Australia, Cleveland Clinic, Hawaii, Mayo Clinic, and UCSF sites.
f. Unrelated population-based control participants ascertained through Medicare, driver's license files, telephone subscription lists or electoral roles by Australia, Ontario, Seattle sites. Family members of population-based controls were recruited by Australia.

 

TABLE 2. FAMILY DATA
    Male Female Total
A.Population Based Case Colon Cancer Families      
Probandsb Baseline epi dataa 4317 4418 8735
  1st Follow-up epi data 2649 2979 5628
  2nd Follow-up epi data 1852 2130 3982
  3rd Follow-up epi data 1184 1428 2612
  4th Follow-up epi data 515 659 1174
  FFQ datae 2093 2406 4499
  Blood/buccal samples 3755 3847 7602
  Polyp material 18 11 29
  Tumor material 3572 3452 7024
  (CRC tumor material)i 3531 3389 6920
  (Other tumor material)j 97 153 250
  Clinical Dx and Treatment Info 2039 2001 4040
 Relativesc Baseline epi dataa 7734 10332 18066
  1st Follow-up epi data 6041 8326 14367
  2nd Follow-up epi data 4694 6615 11309
  3rd Follow-up epi data 3177 4527 7704
  4th Follow-up epi data 1313 1924 3237
  FFQ datae 3276 4617 7893
  Blood/buccal samples 4475 6366 10841
  Polyp material 9 12 21
  Tumor material 314 385 699
  (CRC tumor material)i 248 261 509
  (Other tumor material)j 79 147 226
  Clinical Dx and Treatment info 50 53 103
Spouse Controlsf Baseline epi dataa 363 560 923
  1st Follow-up epi data 296 482 778
  2nd Follow-up epi data 230 389 619
  3rd Follow-up epi data 172 303 475
  4th Follow-up epi data 87 140 227
  FFQ datae 211 318 529
  Blood/buccal samples 326 509 835
  Polyp material 0 0 0
  Tumor material 4 10 14
  (CRC tumor material)i 1 4 5
  (Other tumor material)j 3 6 9
   Clinical Dx and Treatment info  0  0  0
B.Population Based Control Colon Cancer Families      
Probandsd Baseline epi dataa 2071 2204 4275
  1st Follow-up epi data 668 591 1259
  2nd Follow-up epi data 335 279 614
  3rd Follow-up epi data 0 0 0
  4th Follow-up epi data 0 0 0
  FFQ datae 1151 1024 2175
  Blood/buccal samples 1357 1419 2776
  Polyp material 0 0 0
  Tumor material 0 0 0
  (CRC tumor material)i 0 0 0
  (Other tumor material)j 0 0 0
  Clinical Dx and Treatment Info 0 0 0
 Relativesg Baseline epi dataa 310 467 777
  1st Follow-up epi data 0 0 0
  2nd Follow-up epi data 0 0 0
  3rd Follow-up epi data 0 0 0
  4th Follow-up epi data 0 0 0
  FFQ datae 259 382 641
  Blood/buccal samples 5 5 10
  Polyp material 0 0 0
  Tumor material 0 0 0
  (CRC tumor material)i 0 0 0
  (Other tumor material)j 0 0 0
  Clinical Dx and Treatment info 0 0 0
         
C.Clinic Based Colon Cancer Families*      
Affected Probandsb Baseline epi dataa 707 649 1356
  1st Follow-up epi data 510 501 1011
  2nd Follow-up epi data 378 401 779
  3rd Follow-up epi data 228 248 476
  4th Follow-up epi data 69 87 156
  FFQ datae 236 252 488
  Blood/buccal samples 628 592 1220
  Polyp material 21 24 45
  Tumor material 590 539 1129
  (CRC tumor material)i 581 524 1105
  (Other tumor material)j 77 98 175
  Clinical Dx and Treatment info 358 295 653
 Unaffected Probandsd Baseline epi dataa 129 300 429
  1st Follow-up epi data 121 277 398
  2nd Follow-up epi data 103 237 340
  3rd Follow-up epi data 60 130 190
  4th Follow-up epi data 14 40 54
  FFQ datae 72 183 255
  Blood/buccal samples 110 265 375
  Polyp material 18 34 52
  Tumor material 29 85 114
  (CRC tumor material)i 1 8 9
  (Other tumor material)j 28 81 109
  Clinical Dx and Treatment info 3 4 7
Relativesh Baseline epi dataa 3523 4399 7923
  1st Follow-up epi data 3015 3817 6833
  2nd Follow-up epi data 2450 3165 5616
  3rd Follow-up epi data 1440 1952 3392
  4th Follow-up epi data 385 583 968
  FFQ datae 1922 2564 4486
  Blood/buccal samples 3010 3861 6871
  Polyp material 124 133 257
  Tumor material 485 605 1090
  (CRC tumor material)i 338 375 713
  (Other tumor material)j 173 277 450
  Clinical Dx and Treatment info 15 6 21

 

a. Baseline epi data (excluding proxy completion) for females and males

b. Affected with colorectal cancer at baseline interview or biospecimen collection

c. Affected and unaffected, blood and non-blood, relatives of population based case probands, at baseline interview.

d. No history of colon cancer at baseline interview.

e. Food Frequency Questionnaire

f. Non blood relation and spouse of case proband recruited to serve as a control.

g. Affected and unaffected, blood and non-blood, relatives of population based control probands, at baseline interview.

h. Affected and unaffected, blood and non-blood, relatives of clinic based probands, at baseline interview or biospecimen collection.

i. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

j. Individuals diagnosed with non-colorectal cancer and at least one tumor specimen obtained. 

* Includes all clinic-based probands and their blood or non-blood relatives
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