Summary Data

TABLE 1. FAMILY RECRUITMENT^a

	Male	Female	Total

Population-based Families*			13190
Case probands^b	4321	4419	8740
Affected relatives^b	334	370	704
Unaffected relatives^c	7768	10517	18285
Control probands^c	2071	2205	4276
Relatives of controls (Australia only)	310	467	777
Total population-based individuals	14804	17978	32782

Clinic-based Families**			1859
Affected probands^b	697	644	1341
Unaffected probands^c	139	304	443
Affected relatives^b	441	461	902
Unaffected relatives^c	3083	3941	7019
Total clinic-based individuals	4360	5350	9711

Total Individuals	19164	23328	42493
Total Families			15049

* Includes population-based case proband families from all sites and population-based control proband families from Australia site.

** Includes all clinic-based proband families (counts family ID of affected and unaffected clinic-based probands).

a. Baseline epi data (excluding proxy completion) for females and males

b. Affected with colorectal cancer at baseline interview or biospecimen collection

c. No history of colorectal cancer at baseline interview or biospecimen collection

Note: Blood and non-blood relatives/individuals excluding the probands.

TABLE 2. FAMILY DATA^a

		Male	Female	Total
A.Population Based Case Colon Cancer Families
Probands^b	Baseline epi data^a	4321	4419	8740
	1st Follow-up epi data	2635	2966	5601
	2nd Follow-up epi data	1784	2059	3843
	3rd Follow-up epi data	849	1020	1869
	FFQ data^e	2094	2406	4500
	Blood/buccal samples	3773	3855	7628
	Polyp material	15	8	23
	Tumor material	3506	3397	6903
	(CRC tumor material)ⁱ	3461	3335	6796
	(Other tumor material)^j	106	147	253
	Clinical Dx and Treatment info	1817	1801	3618
Relatives^c	Baseline epi data^a	7740	10326	18066
	1st Follow-up epi data	5962	8222	14184
	2nd Follow-up epi data	4334	6104	10438
	3rd Follow-up epi data	2302	3237	5539
	FFQ data^e	3279	4616	7895
	Blood/buccal samples	4730	6667	11397
	Polyp material	8	12	20
	Tumor material	300	367	667
	(CRC tumor material)ⁱ	236	244	480
	(Other tumor material)^j	75	144	219
	Clinical Dx and Treatment info	49	50	99
Spouse Controls^f	Baseline epi data^a	361	561	923
	1st Follow-up epi data	292	483	775
	2nd Follow-up epi data	221	384	605
	3rd Follow-up epi data	148	252	400
	FFQ data^e	210	318	528
	Blood/buccal samples	325	510	835
	Polyp material	0	0	0
	Tumor material	4	10	14
	(CRC tumor material)ⁱ	1	3	4
	(Other tumor material)^j	3	7	10
	Clinical Dx and Treatment info	0	0	0

B.Population Based Control Colon Cancer Families
Probands^d	Baseline epi data^a	2071	2205	4276
	1st Follow-up epi data	669	594	1263
	2nd Follow-up epi data	339	280	619
	3rd Follow-up epi data	0	0	0
	FFQ data^e	1151	1025	2176
	Blood/buccal samples	1364	1424	2788
	Polyp material	0	0	0
	Tumor material	0	0	0
	(CRC tumor material)ⁱ	0	0	0
	(Other tumor material)^j	0	0	0
	Clinical Dx and Treatment info	0	0	0
Relatives^g	Baseline epi data^a	310	467	777
	1st Follow-up epi data	0	0	0
	2nd Follow-up epi data	0	0	0
	3rd Follow-up epi data	0	0	0
	FFQ data^e	259	382	641
	Blood/buccal samples	5	5	10
	Polyp material	0	0	0
	Tumor material	0	0	0
	(CRC tumor material)ⁱ	0	0	0
	(Other tumor material)^j	0	0	0
	Clinical Dx and Treatment info	0	0	0

C.Clinic Based Colon Cancer Families*
Affected Probands^b	Baseline epi data^a	697	644	1341
	1st Follow-up epi data	492	486	978
	2nd Follow-up epi data	316	322	638
	3rd Follow-up epi data	124	140	264
	FFQ data^e	235	252	487
	Blood/buccal samples	626	596	1222
	Polyp material	20	22	42
	Tumor material	568	528	1096
	(CRC tumor material)ⁱ	557	511	1068
	(Other tumor material)^j	81	95	176
	Clinical Dx and Treatment info	321	257	578
Unaffected Probands^d	Baseline epi data^a	139	304	443
	1st Follow-up epi data	125	276	401
	2nd Follow-up epi data	81	172	253
	3rd Follow-up epi data	33	70	117
	FFQ data^e	73	183	256
	Blood/buccal samples	127	283	410
	Polyp material	18	34	52
	Tumor material	31	86	117
	(CRC tumor material)ⁱ	1	9	10
	(Other tumor material)^j	30	82	112
	Clinical Dx and Treatment info	2	1	3
Relatives^h	Baseline epi data^a	3524	4402	7927
	1st Follow-up epi data	2939	3733	6673
	2nd Follow-up epi data	1963	2595	4558
	3rd Follow-up epi data	840	1208	2048
	FFQ data^e	1922	2564	4486
	Blood/buccal samples	3039	3910	6950
	Polyp material	123	131	254
	Tumor material	472	585	1057
	(CRC tumor material)ⁱ	321	355	676
	(Other tumor material)^j	170	276	446
	Clinical Dx and Treatment info	14	7	21

a. Baseline epi data (excluding proxy completion) for females and males

b. Affected with colorectal cancer at baseline interview or biospecimen collection

c. Affected and unaffected, blood and non-blood, relatives of population based case probands, at baseline interview.

d. No history of colon cancer at baseline interview.

e. Food Frequency Questionnaire

f. Non blood relation and spouse of case proband recruited to serve as a control.

g. Affected and unaffected, blood and non-blood, relatives of population based control probands, at baseline interview.

h. Affected and unaffected, blood and non-blood, relatives of clinic based probands, at baseline interview or biospecimen collection.

i. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

j. Individuals diagnosed with non-colorectal cancer and at least one tumor specimen obtained.

* Includes all clinic-based probands and their blood or non-blood relatives

Summary tables - September 2018

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