Summary Data

cfr infographic09jun22

TABLE 1. FAMILY RECRUITMENT

	Male	Female	Total

Population-based Families^a			13,188
Case probands^{c, f}	4,321	4,418	8,739
Affected relatives^{e, f}	338	380	718
Unaffected relatives^{e, g}	7,395	9,958	17,354
Spouse Controls^{g, h}	366	562	928
Unrelated control probands^{g, i}	2,071	2,204	4,275
Relatives of controls (Australia only)^j	310	467	777
Total population-based individuals	14,801	17,989	32,791

Clinic-based Families^b			1,860
Affected probands^{d, f}	707	648	1,355
Unaffected probands^{d, g}	130	300	430
Affected relatives^{e, f}	444	467	912
Unaffected relatives^{e, g}	3,079	3,933	7,012
Total clinic-based individuals	4,360	5,348	9,709

Total Individuals	19,161	23,337	42,500
Total Families			15,048

TABLE 2. FAMILY DATA

		Male	Female	Total
A. Population-Based Case Families^a
Case Probands^{c, f}	Baseline epidemiologic/risk factor survey data^k	4,321	4,418	8,739
	1st Follow-upepidemiologic/risk factor survey data^l	2,600	2,913	5,513
	2nd Follow-up epidemiologic/risk factor survey data^l	1,847	2,112	3959
	3rd Follow-up epidemiologic/risk factor survey data^l	1,273	1,529	2,802
	4th Follow-up epidemiologic/risk factor survey data^l	575	726	1,301
	Food Frequency Questionnaire (FFQ) data^m	2,094	2,406	4,500
	Blood/buccal samples	3,770	3,853	7,623
	Polyp material	18	11	29
	Tumor material:	3,574	3,452	7,026
	CRC tumor material^{f, n}	3,532	3,389	6,921
	Other (extracolonic) tumor material^o	98	153	251
	Clinical diagnosis and treatment data^p	2,048	2,005	4,053
	Pathology reports	3600	3769	7369
Relatives^e	Baseline epidemiologic/risk factor survey data^k	7,733	10,338	18,072
	1st Follow-up epidemiologic/risk factor survey data^l	6,028	8,275	14,304
	2nd Follow-up epidemiologic/risk factor survey data^l	4,729	6,640	11,370
	3rd Follow-up epidemiologic/risk factor survey data^l	3,342	4,777	8,120
	4th Follow-up epidemiologic/risk factor survey data^l	1,628	2,378	4,006
	Food Frequency Questionnaire (FFQ) data^m	3,274	4,619	7,893
	Blood/buccal samples	4,700	6,635	11,335
	Polyp material	9	12	21
	Tumor material:	315	385	700
	CRC tumor material^{f, n}	248	261	509
	Other (extracolonic) tumor material^o	80	147	227
	Clinical diagnosis and treatment data^p	52	54	106
	Pathology reports	250	271	521
Spouse Controls^{h, g}	Baseline epidemiologic/risk factor survey data^k	366	562	928
	1st Follow-up epidemiologic/risk factor survey data^l	286	457	743
	2nd Follow-up epidemiologic/risk factor survey data^l	227	379	606
	3rd Follow-up epidemiologic/risk factor survey data^l	176	305	481
	4th Follow-up epidemiologic/risk factor survey data^l	104	176	280
	Food Frequency Questionnaire (FFQ) data^m	211	318	529
	Blood/buccal samples	328	511	839
	Polyp material	0	0	0
	Tumor material:	4	10	14
	CRC tumor material^{f, n}	1	4	5
	Other (extracolonic) tumor material^o	3	6	9
	Clinical diagnosis and treatment data^p	0	0	0
	Pathology reports	1	3	4
B. Population-Based Control Families
Probandsⁱ	Baseline epidemiologic/risk factor survey data^k	2,071	2,204	4,275
	1st Follow-up epidemiologic/risk factor survey data^l	668	591	1,259
	2nd Follow-up epidemiologic/risk factor survey data^l	335	279	614
	3rd Follow-up epidemiologic/risk factor survey data^l	0	0	0
	4th Follow-up epidemiologic/risk factor survey data^l	0	0	0
	Food Frequency Questionnaire (FFQ) data^m	1,151	1,024	2,175
	Blood/buccal samples	1,360	1,420	2,780
	Polyp material	0	0	0
	Tumor material:	0	0	0
	CRC tumor material^{f, n}	0	0	0
	Other (extracolonic) tumor material^o	0	0	0
	Clinical diagnosis and treatment data^p	0	0	0
	Pathology reports
Relatives^j	Baseline epidemiologic/risk factor survey data^k	310	467	777
	1st Follow-up epidemiologic/risk factor survey data^l	0	0	0
	2nd Follow-up epidemiologic/risk factor survey data^l	0	0	0
	3rd Follow-up epidemiologic/risk factor survey data^l	0	0	0
	4th Follow-up epidemiologic/risk factor survey data^l	0	0	0
	Food Frequency Questionnaire (FFQ) data^m	259	382	641
	Blood/buccal samples	5	5	10
	Polyp material	0	0	0
	Tumor material:	0	0	0
	CRC tumor material^{f, n}	0	0	0
	Other (extracolonic) tumor material^o	0	0	0
	Clinical diagnosis and treatment data^p	0	0	0
	Pathology reports	0	0	0
C. Clinic-Based Families^b
Affected Probands^{d, f}	Baseline epidemiologic/risk factor survey data^k	707	648	1,355
	1st Follow-up epidemiologic/risk factor survey data^l	511	502	1,013
	2nd Follow-up epidemiologic/risk factor survey data^l	392	410	802
	3rd Follow-up epidemiologic/risk factor survey data^l	249	261	510
	4th Follow-up epidemiologic/risk factor survey data^l	82	102	184
	Food Frequency Questionnaire (FFQ) data^m	236	252	488
	Blood/buccal samples	635	600	1,235
	Polyp material	21	24	45
	Tumor material:	590	538	1,128
	CRC tumor material^{f, n}	581	523	1,104
	Other (extracolonic) tumor material^o	77	98	175
	Clinical diagnosis and treatment data^p	359	295	654
	Pathology reports	511	455	966
Unaffected Probands^{d, g}	Baseline epidemiologic/risk factor survey data^k	130	300	430
	1st Follow-up epidemiologic/risk factor survey data^l	122	277	399
	2nd Follow-up epidemiologic/risk factor survey data^l	107	246	353
	3rd Follow-up epidemiologic/risk factor survey data^l	65	144	209
	4th Follow-up epidemiologic/risk factor survey data^l	22	51	73
	Food Frequency Questionnaire (FFQ) data^m	72	183	255
	Blood/buccal samples	117	278	395
	Polyp material	18	34	52
	Tumor material:	30	85	115
	CRC tumor material^{f, n}	2	8	10
	Other (extracolonic) tumor material^o	28	81	109
	Clinical diagnosis and treatment data^p	3	4	7
	Pathology reports	16	22	38
Relatives^e	Baseline epidemiologic/risk factor survey data^k	3,523	4,400	7,924
	1st Follow-up epidemiologic/risk factor survey data^l	3,019	3,822	6,842
	2nd Follow-up epidemiologic/risk factor survey data^l	2,498	3,214	5,713
	3rd Follow-up epidemiologic/risk factor survey data^l	1,570	2,118	3,688
	4th Follow-up epidemiologic/risk factor survey data^l	516	795	1,311
	Food Frequency Questionnaire (FFQ) data^m	1,922	2,564	4,486
	Blood/buccal samples	3,037	3,907	6,945
	Polyp material	124	133	257
	Tumor material:	484	607	1,091
	CRC tumor material^{f, n}	337	377	714
	Other (extracolonic) tumor material^o	173	277	450
	Clinical diagnosis and treatment data^p	15	6	21
	Pathology reports	317	333	651

a. Population-based families include colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registries and their CRC-affected and -unaffected family members (all CCFR sites); unrelated population-based control probands (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia); spouse controls (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia), unaffected family member controls (Cedars-Sinai/USC consortium).

b. Clinic-based families include CRC-affected and -unaffected probands ascertained through genetic and family cancer clinics and their CRC-affected and unaffected family members(Cleveland Clinic, Fred Hutch/Seattle, Mayo Clinic, Sinai Health System/Ontario, Univ of Melbourne/Australia).

c. Population-based colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registry.

d. Clinic-based probands, defined as the first family member ascertained through a genetic or family cancer clinic. Clinic-based probands may be CRC-affected or -unaffected at baseline epidemiologic/risk factors survey.

e. Relative of proband includes blood and non-blood related and may be CRC-affected or -unaffected.

f. CRC-affected at baseline epidemiologic/risk factors survey. CRC is defined as a malignant tumor in ICD-0 sites codes C18.0 - C18.9, C19.9, C20.0, C21.8, and C26.0.

g. CRC-unaffected at baseline epidemiologic/risk factors survey.

h. Spouse of population-based case proband recruited to serve as a control (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia, and UCSF).

i. Unrelated population-based control probands unaffected with CRC at baseline and ascertained through Medicare, driver's license files, telephone subscription lists or electoral roles (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia).

j. Family members of population-based controls (Australia). These may be CRC-affected or -unaffected.

k. Baseline epidemiologic/risk factor survey data (excluding proxy completion)

l. Follow-up epidemiologic/risk factor survey data. These are attempted every 4-5 years beginning in Phase II among Phase I enrollees (excluding population-based controls).

m. Food Frequency Questionnaire (FFQ). Hawaii FFQ version administered at baseline (Sinai Health System/Ontario, Univ of Hawaii, UCSF, Cedars-Sinai/USC consortium, Cleveland Clinic). Australia FFQ administered at baseline (Univ of Melbourne/Australia).

n. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

o. Individuals diagnosed with extracolonic cancer and at least one tumor specimen obtained.

p. Clinical diagnosis and treatment data were collected approximately 4 years after CRC diagnosis for Phase I enrolled CRC-affected probands (all sites except Cedars-Sinai/USC consortium and UCSF).

Summary Data - July 2022

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