TABLE 1. FAMILY RECRUITMENT
|TABLE 2. FAMILY DATA|
a. Population-based families include colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registries and their CRC-affected and -unaffected family members (all CCFR sites); unrelated population-based control probands (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia); spouse controls (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia), unaffected family member controls (Cedars-Sinai/USC consortium).
b. Clinic-based families include CRC-affected and -unaffected probands ascertained through genetic and family cancer clinics and their CRC-affected and unaffected family members(Cleveland Clinic, Fred Hutch/Seattle, Mayo Clinic, Sinai Health System/Ontario, Univ of Melbourne/Australia).
c. Population-based colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registry.
d. Clinic-based probands, defined as the first family member ascertained through a genetic or family cancer clinic. Clinic-based probands may be CRC-affected or -unaffected at baseline epidemiologic/risk factors survey.
e. Relative of proband includes blood and non-blood related and may be CRC-affected or -unaffected.
f. CRC-affected at baseline epidemiologic/risk factors survey. CRC is defined as a malignant tumor in ICD-0 sites codes C18.0 - C18.9, C19.9, C20.0, C21.8, and C26.0.
g. CRC-unaffected at baseline epidemiologic/risk factors survey.
h. Spouse of population-based case proband recruited to serve as a control (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia, and UCSF).
i. Unrelated population-based control probands unaffected with CRC at baseline and ascertained through Medicare, driver's license files, telephone subscription lists or electoral roles (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia).
j. Family members of population-based controls (Australia). These may be CRC-affected or -unaffected.
k. Baseline epidemiologic/risk factor survey data (excluding proxy completion)
l. Follow-up epidemiologic/risk factor survey data. These are attempted every 4-5 years beginning in Phase II among Phase I enrollees (excluding population-based controls).
m. Food Frequency Questionnaire (FFQ). Hawaii FFQ version administered at baseline (Sinai Health System/Ontario, Univ of Hawaii, UCSF, Cedars-Sinai/USC consortium, Cleveland Clinic). Australia FFQ administered at baseline (Univ of Melbourne/Australia).
n. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.
o. Individuals diagnosed with extracolonic cancer and at least one tumor specimen obtained.
p. Clinical diagnosis and treatment data were collected approximately 4 years after CRC diagnosis for Phase I enrolled CRC-affected probands (all sites except Cedars-Sinai/USC consortium and UCSF).