cfr infographic09jun22

 

 

TABLE 1. FAMILY RECRUITMENT

  Male Female Total
       
Population-based Familiesa     13,188
Case probandsc, f 4,321 4,418 8,739
Affected relativese, f 338 380 718
Unaffected relativese, g 7,395 9,958 17,354
Spouse Controlsg, h 366 562 928
Unrelated control probandsg, i 2,071 2,204 4,275
Relatives of controls (Australia only)j 310 467 777
 Total population-based individuals 14,801 17,989 32,791
       
Clinic-based Familiesb     1,860
Affected probandsd, f 707 648 1,355
Unaffected probandsd, g 130 300 430
Affected relativese, f 444 467 912
Unaffected relativese, g 3,079 3,933 7,012
Total clinic-based individuals 4,360 5,348 9,709
       
Total Individuals 19,161 23,337 42,500
Total Families     15,048

 

 

TABLE 2. FAMILY DATA
    Male Female Total
A. Population-Based Case Familiesa      
Case Probandsc, f Baseline epidemiologic/risk factor survey datak 4,321 4,418  8,739 
  1st Follow-upepidemiologic/risk factor survey datal 2,600 2,913 5,513
  2nd Follow-up epidemiologic/risk factor survey datal 1,847 2,112 3959
  3rd Follow-up epidemiologic/risk factor survey datal 1,273 1,529 2,802
  4th Follow-up epidemiologic/risk factor survey datal 575 726 1,301
  Food Frequency Questionnaire (FFQ) datam 2,094 2,406 4,500
  Blood/buccal samples 3,770 3,853 7,623
  Polyp material 18 11 29
  Tumor material: 3,574 3,452 7,026
        CRC tumor materialf, n 3,532 3,389 6,921
       Other (extracolonic) tumor materialo 98 153 251
  Clinical diagnosis and treatment datap 2,048 2,005 4,053
  Pathology reports 3600  3769  7369 
 Relativese Baseline epidemiologic/risk factor survey datak 7,733 10,338 18,072
  1st Follow-up epidemiologic/risk factor survey datal 6,028 8,275 14,304
  2nd Follow-up epidemiologic/risk factor survey datal 4,729 6,640 11,370
  3rd Follow-up epidemiologic/risk factor survey datal 3,342 4,777 8,120
  4th Follow-up epidemiologic/risk factor survey datal 1,628 2,378 4,006
  Food Frequency Questionnaire (FFQ) datam 3,274 4,619 7,893
  Blood/buccal samples 4,700 6,635 11,335
  Polyp material 9 12 21
  Tumor material: 315 385 700
        CRC tumor materialf, n 248 261 509
        Other (extracolonic) tumor materialo 80 147 227
  Clinical diagnosis and treatment datap 52 54 106
  Pathology reports 250  271  521 
Spouse Controlsh, g Baseline epidemiologic/risk factor survey datak 366 562 928
  1st Follow-up epidemiologic/risk factor survey datal 286 457 743
  2nd Follow-up epidemiologic/risk factor survey datal 227 379 606
  3rd Follow-up epidemiologic/risk factor survey datal 176 305 481
  4th Follow-up epidemiologic/risk factor survey datal 104 176 280
  Food Frequency Questionnaire (FFQ) datam 211 318 529
  Blood/buccal samples 328 511 839
  Polyp material 0 0 0
  Tumor material: 4 10 14
        CRC tumor materialf, n 1 4 5
        Other (extracolonic) tumor materialo 3 6 9
  Clinical diagnosis and treatment datap  0  0  0
  Pathology reports  1
B. Population-Based Control Families      
Probandsi Baseline epidemiologic/risk factor survey datak 2,071 2,204 4,275
  1st Follow-up epidemiologic/risk factor survey datal 668 591 1,259
  2nd Follow-up epidemiologic/risk factor survey datal 335 279 614
  3rd Follow-up epidemiologic/risk factor survey datal 0 0 0
  4th Follow-up epidemiologic/risk factor survey datal 0 0 0
  Food Frequency Questionnaire (FFQ) datam 1,151 1,024 2,175
  Blood/buccal samples 1,360 1,420 2,780
  Polyp material 0 0 0
  Tumor material: 0 0 0
        CRC tumor materialf, n 0 0 0
        Other (extracolonic) tumor materialo 0 0 0
  Clinical diagnosis and treatment datap 0 0 0
  Pathology reports      
 Relativesj Baseline epidemiologic/risk factor survey datak 310 467 777
  1st Follow-up epidemiologic/risk factor survey datal 0 0 0
  2nd Follow-up epidemiologic/risk factor survey datal 0 0 0
  3rd Follow-up epidemiologic/risk factor survey datal 0 0 0
  4th Follow-up epidemiologic/risk factor survey datal 0 0 0
  Food Frequency Questionnaire (FFQ) datam 259 382 641
  Blood/buccal samples 5 5 10
  Polyp material 0 0 0
  Tumor material: 0 0 0
        CRC tumor materialf, n 0 0 0
        Other (extracolonic) tumor materialo 0 0 0
  Clinical diagnosis and treatment datap 0 0 0
   Pathology reports 0 0
C. Clinic-Based Familiesb      
Affected Probandsd, f Baseline epidemiologic/risk factor survey datak 707 648 1,355
  1st Follow-up epidemiologic/risk factor survey datal 511 502 1,013
  2nd Follow-up epidemiologic/risk factor survey datal 392 410 802
  3rd Follow-up epidemiologic/risk factor survey datal 249 261 510
  4th Follow-up epidemiologic/risk factor survey datal 82 102 184
  Food Frequency Questionnaire (FFQ) datam 236 252 488
  Blood/buccal samples 635 600 1,235
  Polyp material 21 24 45
  Tumor material: 590 538 1,128
        CRC tumor materialf, n 581 523 1,104
        Other (extracolonic) tumor materialo 77 98 175
  Clinical diagnosis and treatment datap 359 295 654
  Pathology reports 511  455  966 
 Unaffected Probandsd, g Baseline epidemiologic/risk factor survey datak 130 300 430
  1st Follow-up epidemiologic/risk factor survey datal 122 277 399
  2nd Follow-up epidemiologic/risk factor survey datal 107 246 353
  3rd Follow-up epidemiologic/risk factor survey datal 65 144 209
  4th Follow-up epidemiologic/risk factor survey datal 22 51 73
  Food Frequency Questionnaire (FFQ) datam 72 183 255
  Blood/buccal samples 117 278 395
  Polyp material 18 34 52
  Tumor material: 30 85 115
        CRC tumor materialf, n 2 8 10
        Other (extracolonic) tumor materialo 28 81 109
  Clinical diagnosis and treatment datap 3 4 7
  Pathology reports 16  22  38 
Relativese Baseline epidemiologic/risk factor survey datak 3,523 4,400 7,924
  1st Follow-up epidemiologic/risk factor survey datal 3,019 3,822 6,842
  2nd Follow-up epidemiologic/risk factor survey datal 2,498 3,214 5,713
  3rd Follow-up epidemiologic/risk factor survey datal 1,570 2,118 3,688
  4th Follow-up epidemiologic/risk factor survey datal 516 795 1,311
  Food Frequency Questionnaire (FFQ) datam 1,922 2,564 4,486
  Blood/buccal samples 3,037 3,907 6,945
  Polyp material 124 133 257
  Tumor material: 484 607 1,091
        CRC tumor materialf, n 337 377 714
        Other (extracolonic) tumor materialo 173 277 450
  Clinical diagnosis and treatment datap 15 6 21
  Pathology reports 317  333  651 

 

a. Population-based families include colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registries and their CRC-affected and -unaffected family members (all CCFR sites); unrelated population-based control probands (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia); spouse controls (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia), unaffected family member controls (Cedars-Sinai/USC consortium). 

b. Clinic-based families include CRC-affected and -unaffected probands ascertained through genetic and family cancer clinics and their CRC-affected and unaffected family members(Cleveland Clinic, Fred Hutch/Seattle, Mayo Clinic, Sinai Health System/Ontario, Univ of Melbourne/Australia).

c. Population-based colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registry.

d. Clinic-based probands, defined as the first family member ascertained through a genetic or family cancer clinic. Clinic-based probands may be CRC-affected or -unaffected at baseline epidemiologic/risk factors survey.

e. Relative of proband includes blood and non-blood related and may be CRC-affected or -unaffected.

f. CRC-affected at baseline epidemiologic/risk factors survey. CRC is defined as a malignant tumor in ICD-0 sites codes C18.0 - C18.9, C19.9, C20.0, C21.8,  and C26.0.

g. CRC-unaffected at baseline epidemiologic/risk factors survey. 

h. Spouse of population-based case proband recruited to serve as a control (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia, and UCSF).

i. Unrelated population-based control probands unaffected with CRC at baseline and ascertained through Medicare, driver's license files, telephone subscription lists or electoral roles (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia). 

j. Family members of population-based controls (Australia). These may be CRC-affected or -unaffected.

k. Baseline epidemiologic/risk factor survey data (excluding proxy completion)

l. Follow-up epidemiologic/risk factor survey data. These are attempted every 4-5 years beginning in Phase II among Phase I enrollees (excluding population-based controls).

m. Food Frequency Questionnaire (FFQ). Hawaii FFQ version administered at baseline (Sinai Health System/Ontario, Univ of Hawaii, UCSF, Cedars-Sinai/USC consortium, Cleveland Clinic). Australia FFQ administered at baseline (Univ of Melbourne/Australia).

n. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

o. Individuals diagnosed with extracolonic cancer and at least one tumor specimen obtained. 

p. Clinical diagnosis and treatment data were collected approximately 4 years after CRC diagnosis for Phase I enrolled CRC-affected probands (all sites except Cedars-Sinai/USC consortium and UCSF).