TABLE 1. FAMILY RECRUITMENTa
 
  Male Female Total
       
Population-based Families*     13190
Case probandsb 4321 4419 8740
Affected relativesb 332 372 704
Unaffected relativesc 7769 10516 18285
Control probandsc 2071 2205 4276
Relatives of controls (Australia only) 310 467 777
Total population-based individuals 14803 17979 32782
       
Clinic-based Families**     1859
Affected probandsb 699 644 1343
Unaffected probandsc 137 304 441
Affected relativesb 439 464 904
Unaffected relativesc 3084 3935 7019
Total clinic-based individuals 4359 5347 9707
       
Total Individuals 19162 23326 42489
Total Families     15049
* Includes population-based case proband families from all sites and population-based control proband families from Australia site.
** Includes all clinic-based proband families (counts family ID of affected and unaffected clinic-based probands).
a. Baseline epi data (excluding proxy completion) for females and males
b. Affected with colorectal cancer at baseline interview or biospecimen collection
c. No history of colorectal cancer at baseline interview or biospecimen collection
Note: Blood and non-blood relatives/individuals excluding the probands.

 

TABLE 2. FAMILY DATAa
    Male Female Total
A.Population Based Case Colon Cancer Families      
Probandsb Baseline epi dataa 4321 4419 8740
  1st Follow-up epi data 2623 2955 5578
  2nd Follow-up epi data 1732 2022 3754
  3rd Follow-up epi data 750 952 1702
  FFQ datae 2094 2406 4500
  Blood/buccal samples 3697 3794 7491
  Polyp material 14 8 22
  Tumor material 3503 3397 6900
  (CRC tumor material)i 3458 3334 6792
  (Other tumor material)j 103 149 252
  Clinical Dx and Treatment info 1779 1754 3533
Relativesc Baseline epi dataa 7740 10328 18068
  1st Follow-up epi data 5910 8156 14066
  2nd Follow-up epi data 4162 5863 10025
  3rd Follow-up epi data 1990 2823 4813
  FFQ datae 3279 4616 7895
  Blood/buccal samples 4707 6623 11330
  Polyp material 7 10 17
  Tumor material 285 352 637
  (CRC tumor material)i 224 235 459
  (Other tumor material)j 71 138 209
  Clinical Dx and Treatment info 49 50 99
Spouse Controlsf Baseline epi dataa 361 560 921
  1st Follow-up epi data 292 482 774
  2nd Follow-up epi data 216 375 591
  3rd Follow-up epi data 124 191 315
  FFQ datae 210 318 528
  Blood/buccal samples 325 509 834
  Polyp material 0 0 0
  Tumor material 2 8 10
  (CRC tumor material)i 1 2 3
  (Other tumor material)j 1 6 7
  Clinical Dx and Treatment info 0 0 0
         
B.Population Based Control Colon Cancer Families      
Probandsd Baseline epi dataa 2071 2205 4276
  1st Follow-up epi data 667 594 1261
  2nd Follow-up epi data 339 279 618
  3rd Follow-up epi data 0 0 0
  FFQ datae 1151 1025 2176
  Blood/buccal samples 1364 1424 2788
  Polyp material 0 0 0
  Tumor material 0 0 0
  (CRC tumor material)i 0 0 0
  (Other tumor material)j 0 0 0
  Clinical Dx and Treatment info 0 0 0
Relativesg Baseline epi dataa 310 382 641
  1st Follow-up epi data 0 0 0
  2nd Follow-up epi data 0 0 0
  3rd Follow-up epi data 0 0 0
  FFQ datae 259 382 641
  Blood/buccal samples 5 5 10
  Polyp material 0 0 0
  Tumor material 0 0 0
  (CRC tumor material)i 0 0 0
  (Other tumor material)j 0 0 0
  Clinical Dx and Treatment info 0 0 0
         
C.Clinic Based Colon Cancer Control Families*      
Affected Probandsb Baseline epi dataa 699 644 1343
  1st Follow-up epi data 486 481 967
  2nd Follow-up epi data 307 316 623
  3rd Follow-up epi data 109 128 237
  FFQ datae 237 252 489
  Blood/buccal samples 627 594 1221
  Polyp material 21 22 43
  Tumor material 566 520 1086
  (CRC tumor material)i 555 498 1053
  (Other tumor material)j 79 93 172
  Clinical Dx and Treatment info 284 241 525
Unaffected Probandsd Baseline epi dataa 137 304 441
  1st Follow-up epi data 123 273 396
  2nd Follow-up epi data 80 167 247
  3rd Follow-up epi data 31 60 91
  FFQ datae 71 183 254
  Blood/buccal samples 118 277 395
  Polyp material 16 34 50
  Tumor material 29 84 113
  (CRC tumor material)i 1 6 7
  (Other tumor material)j 28 81 109
  Clinical Dx and Treatment info 1 1 2
Relativesh Baseline epi dataa 3523 4399 7923
  1st Follow-up epi data 2915 3705 6621
  2nd Follow-up epi data 1873 2482 4355
  3rd Follow-up epi data 743 1056 1799
  FFQ datae 1922 2564 4486
  Blood/buccal samples 3015 3881 6897
  Polyp material 121 128 249
  Tumor material 436 547 983
  (CRC tumor material)i 290 322 612
  (Other tumor material)j 160 266 426
  Clinical Dx and Treatment info 14 7 21

a. Baseline epi data (excluding proxy completion) for females and males

b. Affected with colorectal cancer at baseline interview or biospecimen collection

c. Affected and unaffected, blood and non-blood, relatives of population based case probands, at baseline interview.

d. No history of colon cancer at baseline interview.

e. Food Frequency Questionnaire

f. Non blood relation and spouse of case proband recruited to serve as a control.

g. Affected and unaffected, blood and non-blood, relatives of population based control probands, at baseline interview.

h. Affected and unaffected, blood and non-blood, relatives of clinic based probands, at baseline interview or biospecimen collection.

i. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

j. Individuals diagnosed with non-colorectal cancer and at least one tumor specimen obtained. 

* Includes all clinic-based probands and their blood or non-blood relatives